94994-39-5

Basic information

• Product Name: 4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID
• Synonyms: 4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID;4-[N-Boc-(methylamino)]butanoic acid;4-(N-BOC-N-METHYL-AMINO)-BUTYRIC ACID;(Tert-Butoxy)Carbonyl N-Me-Abu(4)-OH;Boc-N-methyl-gamma-aminobutyric acid
• CAS NO: 94994-39-5
• Molecular Formula: C₁₀H₁₉NO₄
• Molecular Weight: 217.26216
• Mol File: 94994-39-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 332.5±21.0 °C(Predicted)
• Appearance: /
• Density: 1.091±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.70±0.10(Predicted)
• CAS DataBase Reference: 4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID(94994-39-5)
• EPA Substance Registry System: 4-[(TERT-BUTOXYCARBONYL)(METHYL)AMINO]BUTANOIC ACID(94994-39-5)

Safety Data

• Hazardous Substances Data: 94994-39-5(Hazardous Substances Data)

Usage

Uses

4-((tert-Butoxycarbonyl)(methyl)amino)butanoic Acid is used in preparation of substituted straight chain spiro derivatives as menin/MLL protein/protein interaction inhibitors useful for treating diseases.

Upstream product

• 57294-38-9 N-(tert-butoxycarbonyl)-4-aminobutanoic acid 
• 74-88-4 methyl iodide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1119-48-8 4-(methylamino)butyric acid 
• 133171-74-1 methyl 4-[[(1,1-dimethylethoxy)carbonyl]methylamino]butanoic acid 
• 6976-17-6 4-(methylamino)butyric acid hydrochloride 
• 872-50-4 1-methyl-pyrrolidin-2-one 

Downstream Products

• 876016-45-4 C₂₅H₃₁N₃O₄ 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 1290070-54-0 C₂HF₃O₂*C₁₁H₁₅NO₂ 
• 1290070-21-1 C₁₆H₂₃NO₄ 
• 1253582-10-3 biphenyl-2-ylcarbamic acid 1-[2-({3-[3-(2-{benzyl-[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-(tert-butyldimethylsilanyloxy)ethyl]-amino}ethyl)phenylcarbamoyl]propyl}methylcarbamoyl)ethyl]piperidin-4-yl ester 
• 1253582-11-4 biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-(tert-butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]-ethyl}phenylcarbamoyl)propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester 
• 1253580-03-8 biphenyl-2-ylcarbamic acid 1-(2-{[3-(3-{2-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]ethyl}phenylcarbamoyl)-propyl]methylcarbamoyl}ethyl)piperidin-4-yl ester 
• 1253582-09-0 N-[3-(2-{benzyl-[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-(tert-butyldimethylsilanyloxy)ethyl]amino}ethyl)phenyl]-4-methylaminobutyramide 

Relevant articles and documents

SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES

Provided herein are pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.

DC-SIGN ANTIBODY CONJUGATES COMPRISING STING AGONISTS

Provided herein are immunoconjugates comprising an anti-DC-SiGN antibody conjugated to a STING agonist. Also disclosed are methods of making the immunoconjugates and methods of treating cancer using the immunoconjugates.

Design, synthesis, and cyclization of 4-aminobutyric acid derivatives: Potential candidates as self-immolative spacers

Self-immolative spacers have gained significant interest in recent years due to their utility in numerous prodrug, sensor and drug delivery systems. However, there are a very limited number of spacers that are capable of undergoing spontaneous and rapid reactions under mild conditions. To address this need, 4-aminobutyric acid derivatives were explored as a potential class of self-immolative spacers. Using a modular approach, eleven N- and α-substituted derivatives of 4-aminobutyric acid were synthesized, and their intramolecular cyclizations to γ-lactams were studied. Kinetics experiments were carried out at physiological pH and temperature, and the observed half-lives for the spacers ranged from 2 to 39 s, depending on the molecular structure. In addition, the pH dependence of the cyclization rate was also explored and it was found that cyclization still occurred rapidly at mildly acidic pH. Therefore, this class of compounds exhibits promise for incorporation into a variety of self-immolative systems where rapid cyclization reactions are desired.