950122-50-6Relevant academic research and scientific papers
The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
Heikkilae, Timo,Thirumalairajan, Srinath,Davies, Matthew,Parsons, Mark R.,McConkey, A. Glenn,Fishwick, Colin W. G.,Johnson, A. Peter
, p. 88 - 92 (2006)
The de novo molecular design program SPROUT has been applied to the X-ray crystal structures of Plasmodium and human dihydroorotate dehydrogenase, respectively. The resulting design templates were used to prepare a series of molecules which, in keeping wi
