95021-29-7Relevant academic research and scientific papers
Thermal and microwave-assisted conjugate additions of indole on electron-deficient nitro-olefins
Kusurkar, Radhika S.,Alkobati, Nabil A. H.,Gokule, Anita S.,Chaudhari, Purnima M.,Waghchaure, Prasad B.
, p. 1075 - 1081 (2006)
Conjugate addition of indole on nitro-olefins was carried out by three different methods: (i) thermal heating in a sealed tube, (ii) reaction with indolyl magnesium iodide, and (iii) microwave irradiation. Comparison of the results indicated that the micr
One-Pot Synthesis of 3-(2-Fluoroalkenyl)indoles
Aldoshin, Alexander S.,Tabolin, Andrey A.,Ioffe, Sema L.,Nenajdenko, Valentine G.
, p. 4384 - 4396 (2019/07/03)
An unprecedented one-pot synthesis of 3-(fluoroalkenyl)indoles was developed. This process involves a catalyst-free Michael addition of β-fluoro-β-nitrostyrenes to indoles in neat followed by elimination of HNO2 using DBU as a base. The effectiveness of this approach was demonstrated through the preparation of variety of target products in up to 75 % isolated yield.
Use of the Pictet-Spengler reaction for the synthesis of 1,4-disubstituted-1,2,3,4-tetrahydro-β-carbolines and 1,4-disubstituted-β-carbolines: formation of γ-carbolines
Kusurkar, Radhika S.,Alkobati, Nabil A.H.,Gokule, Anita S.,Puranik, Vedavati G.
, p. 1654 - 1662 (2008/09/17)
Microwave-assisted conjugate addition of indole on nitro-olefins furnished nitro compounds, which were reduced to tryptamines. Further, by using Pictet-Spengler condensation, new 1,4-disubstituted-1,2,3,4-tetrahydro-β-carbolines were synthesized in diaste
Conjugate addition of indoles to nitroalkenes promoted by basic alumina in solventless conditions
Ballini, Roberto,Clemente, Roberto Rabanedo,Palmieri, Alessandro,Petrini, Marino
, p. 191 - 196 (2007/10/03)
Basic alumina is found to promote the conjugate addition of indoles to nitroalkenes in solventless conditions at 60°C. Nitroalkenes can be replaced by nitro alcohols that are converted into nitroolefins under the reaction conditions. Alternatively, a tand
