950224-92-7Relevant academic research and scientific papers
INHIBITORS OF IAP
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, (2011/04/14)
The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula (I), and G, X1, X2, R1, R2, R3, R4/sub
Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres
Cohen, Frederick,Koehler, Michael F.T.,Bergeron, Philippe,Elliott, Linda O.,Flygare, John A.,Franklin, Matthew C.,Gazzard, Lewis,Keteltas, Stephen F.,Lau, Kevin,Ly, Cuong Q.,Tsui, Vickie,Fairbrother, Wayne J.
scheme or table, p. 2229 - 2233 (2010/06/15)
A series of IAP antagonists based on thiazole or benzothiazole amide isosteres was designed and synthesized. These compounds were tested for binding to the XIAP-BIR3 and ML-IAP BIR using a fluorescence polarization assay. The most potent of these compound
