950489-50-6

Upstream product

• 950489-16-4 (3S,4R,5S)-4-bromo-3,5-dimethyl-5-phenyldihydrofuran-2(3H)-one 
• 950489-14-2 (R,E)-2-methyl-4-phenylpent-3-enoic acid 
• 950489-12-0 (R)-3-((R,E)-2-methyl-4-phenylpent-3-enoyl)-4-phenyloxazolidin-2-one 
• 98-86-2 acetophenone 
• 80-62-6 methacrylic acid methyl ester 

Relevant academic research and scientific papers

A new entry to asymmetric synthesis of optically active α,γ-substituted γ-butyrolactones, using a carbohydrate derived amide as both a chiral auxiliary and a proton source

(Chemical Equation Presented) A new entry for the asymmetric synthesis of optically active α,γ-substituted γ-butyrolactones was developed by using a carbohydrate-derived amide as both a chiral auxiliary and a proton source. Unlike the previously reported examples, the chiral auxiliary employed in this reaction also successfully functioned as a protonating agent. Excellent asymmetric induction could be achieved by this dual stereoselective control in the reaction process.

Preparation of enantiopure 3,5,5-trialkyl-γ-butyrolactones by diastereospecific 5-endo halo lactonizations

A new preparation of 3,5,5-trialkyl-γ-butyrolactones of defined absolute configuration is reported. This method involves the diastereoselective alkylation of 3,4-ethylenic acids after incorporation of a chiral Evans auxiliary, and then after separation of

Chiral ligand control in enantioselective reduction of ketones by SmI2 for ketyl radical addition to olefins

Samarium(II) diiodide-mediated reductive coupling of ketones with α,β- unsaturated esters is shown to afford enantioselectively γ-butyrolactones by the addition of 2,2'-bis(diphenylphosphinyl)-1,1'-binaphthyl (BINAPO) as a chiral ligand.