950513-53-8

Upstream product

• 104501-02-2 1-(prop-2-yn-1-yl)-1H-pyrrole-2-carbaldehyde 
• 1003-29-8 2-pyrrole aldehyde 
• 1794-48-5 1-bromo-3-phenylprop-2-yne 
• 591-50-4 iodobenzene 

Downstream Products

• 1335284-38-2 3-benzylpyrrolo[1,2-a]pyrazine 

Relevant academic research and scientific papers

Platinum-catalyzed regioselective hydration of 1-(2-propynyl)-2- formylpyrroles

The hydration reaction of 1-(2-propynyl)-2-formylpyrroles with a platinum catalyst in aqueous media is described. Various 1-(2-oxopropyl)-2-formylpyrroles were regioselectively synthesized Via the platinum-promoted intramolecular 6-exo-dig cyclization pathway.

Cascade synthesis of indolizines and pyrrolo[1,2-a]pyrazines from 2-formyl-1-propargylpyrroles

A straightforward synthesis of indolizines and pyrrolo[1,2-a]pyrazines was performed through a cascade condensation/cyclization/aromatization reaction of substituted 2-formyl-N-propargylpyrroles with active methylene compounds such as nitromethane, alkyl

Mechanistic Insights into the Reaction of N-Propargylated Pyrrole- and Indole-Carbaldehyde with Ammonia, Alkyl Amines, and Branched Amines: A Synthetic and Theoretical Investigation

The reaction of pyrrole- and indole-carbaldehydes having a propargyl group attached to the nitrogen atom with various amines was studied. The reaction with ammonia formed pyrrolo[1,2-a]pyrazine and pyrazino[1,2-a]indole while the reaction with alkylamines

Silver-catalyzed synthesis of pyrrolopiperazine fused with oxazine/imidazole via a domino approach: Evaluation of anti-cancer activity

Silver-catalyzed domino synthesis of pyrrolopiperazine fused with oxazine/imidazole by the reaction of pyrrole-derived δ-alkynyl aldehydes and nucleophilic amines was performed. This domino strategy involves the formation of two new C-N bonds and one C-O/C-N bond, resulting in the formation of two new interesting fused heterocycles. Some of the synthesized compounds exhibit promising growth inhibitory activity against leukemia and breast cancer cell lines.

Synthesis of pyrrole-fused C,N-cyclic azomethine imines and pyrazolopyrrolopyrazines: Analysis of their aromaticity using nucleus-independent chemical shifts values

The AgOTf-catalyzed reaction of C-2 substituted pyrrole hydrazones having an N-propargyl group was studied. The selective 6-endo-dig mode of cyclization was observed, giving rise to the formation of pyrrole-fused C,N-cyclic azomethine imine derivatives. T

Gold-catalyzed oxime-oxime rearrangement

The gold-catalyzed reaction of pyrrole and indole oximes having a propargyl group attached to the nitrogen atom was studied. The selective 6-endo-dig mode of cyclization was observed for the terminal alkynes giving rise to the formation of pyrazine N-oxides in the presence of a gold catalyst. However, the reaction with substituted alkyne transferred the oxime functionality intramolecularly from one carbon atom to another via the 7-endo-dig cyclization process. This transformation is unprecedented in the literature and is named an oxime-oxime rearrangement.

An efficient one-pot synthesis of novel fused pyrroles and indoles by dipolar cycloaddition under microwave and conventional conditions

The straightforward synthesis of families of novel tricyclic and tetracyclic pyrrolino and indolino heterocycles in a one-pot [3+2]-cycloaddition reaction is described. The process enables the synthesis of diversified pyrroles or pyrrolines in high yields