950519-61-6Relevant articles and documents
Discovery of new selective glucocorticoid receptor agonist leads
Berger, Markus,Rehwinkel, Hartmut,Schmees, Norbert,Sch?cke, Heike,Edman, Karl,Wissler, Lisa,Reichel, Andreas,Jaroch, Stefan
, p. 437 - 442 (2017/01/16)
We report on the discovery of two new lead series for the development of glucocorticoid receptor agonists. Firstly, the discovery of tetrahydronaphthalenes led to metabolically stable and dissociated compounds. Their binding mode to the glucocorticoid rec