950567-38-1

Upstream product

• 84382-45-6 1-(4-methoxyphenyl)-2-(pyrrolidin-2-yl)ethan-1-one 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 1042905-10-1 C₁₃H₁₇NO₂*ClH 
• 2881-83-6 ethyl 4-methoxybenzoylacetate 
• 13422-77-0 3-(4-methoxy-phenyl)-3-oxo-propionic acid 

Downstream Products

• 950567-39-2 C₂₁H₂₁NO₂ 

Relevant academic research and scientific papers

Synthesis and evaluation of heteroaromatic 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones for cytotoxicity against the HCT-116 colon cancer cell line

A heteroaromatic 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-one analog library was prepared and tested for cytotoxic properties against the HCT-116 colon cancer cell line, thus providing additional information pertaining to structure-activity relations

Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones

A 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-one library was constructed and tested against the colon cancer cell line HCT-116 as an initial screen for cytotoxic properties. Of this library, the parent compound, in which the southern aromatic ring remains unsubstituted, and the northern aromatic ring carries a 4-methoxy group, exhibited the most potent cytotoxicity with an IC50 value of 0.39 μM and displayed promising activity in vivo in the NCI's mouse hollow fiber assay.