950567-39-2

Usage

Uses

Used in Pharmaceutical Applications:
2,3,8,8a-Tetrahydro-7-(4-methoxyphenyl)-6-phenyl-5(1H)-indolizinone is used as a potential pharmaceutical agent for its potential pharmacological effects. The specific application reason is not detailed in the provided materials, but its unique structure and functional groups suggest it may have therapeutic properties that are yet to be fully explored and understood through further research.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2,3,8,8a-Tetrahydro-7-(4-methoxyphenyl)-6-phenyl-5(1H)-indolizinone is used as a subject of interest for studying its structure-activity relationships and potential interactions with biological targets. This research could lead to the development of new drugs or drug candidates based on its molecular framework.

Upstream product

• 1034128-39-6 1-(4-methoxyphenyl)-2-(1-(2-phenylacetyl)pyrrolidin-2-yl)ethanone 
• 950567-38-1 C₂₁H₂₃NO₃ 
• 2881-83-6 ethyl 4-methoxybenzoylacetate 
• 84382-45-6 1-(4-methoxyphenyl)-2-(pyrrolidin-2-yl)ethan-1-one 
• 13422-77-0 3-(4-methoxy-phenyl)-3-oxo-propionic acid 

Relevant academic research and scientific papers

Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers

An enantiospecific synthesis was developed to generate both enantiomers of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one. A biological assay utilizing the HCT-116 colon cancer cell line to determine the cytotoxicity of these analogs revealed that only the (R)-enantiomer exhibited appreciable cytotoxicity with an IC50 value of 0.2 μM.

Synthesis and evaluation of heteroaromatic 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones for cytotoxicity against the HCT-116 colon cancer cell line

A heteroaromatic 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-one analog library was prepared and tested for cytotoxic properties against the HCT-116 colon cancer cell line, thus providing additional information pertaining to structure-activity relations

Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones

A 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-one library was constructed and tested against the colon cancer cell line HCT-116 as an initial screen for cytotoxic properties. Of this library, the parent compound, in which the southern aromatic ring remains unsubstituted, and the northern aromatic ring carries a 4-methoxy group, exhibited the most potent cytotoxicity with an IC50 value of 0.39 μM and displayed promising activity in vivo in the NCI's mouse hollow fiber assay.