950578-14-0Relevant academic research and scientific papers
Zinc-Catalyzed Enantioselective Hydrosilylation of Ketones and Imines under Solvent-Free Conditions
Szewczyk, Marcin,Bez?ada, Agata,Mlynarski, Jacek
, p. 3575 - 3579 (2016)
The zinc acetate promoted asymmetric hydrosilylation of various ketones and imines under solvent-free conditions was examined by using an unprecedented low catalyst loading. Exposure of ketones to 0.05 mol % Zn-based chiral diamine complex in the presence of triethoxysilane afforded enantioenriched alcohols in excellent yields (up to 98 %) and enantioselectivities (up to 97 % ee). This methodology also allowed for the chemoselective 1,2-reduction of α,β-unsaturated ketones and imines.
