950592-86-6Relevant academic research and scientific papers
Synthesis and anti-human immunodeficiency virus type 1 activity of (e)-n-phenylstyryl-n-alkylacetamide derivatives
Cheng, Pi,Chen, Ji-Jun,Huang, Ning,Wang, Rui-Rui,Zheng, Yong-Tang,Liang, Yi-Zeng
experimental part, p. 3176 - 3186 (2010/01/06)
series of (E)-N-phenylstyry l-N-alkylacetamides, 5, were synthesized by direct reduction-acetylation of β-arylnitroolefins, followed by N-alkylation. The title compounds were characterized by 1H-NMR, EIMS and IR analysis. All the synthesized co
Synthesis and biological evaluation of N-acetyl-β-aryl-1,2-didehydroethylamines as new HIV-1 RT inhibitors in vitro
Cheng, Pi,Jiang, Zhi-Yong,Wang, Rui-Rui,Zhang, Xue-Mei,Wang, Qian,Zheng, Yong-Tang,Zhou, Jun,Chen, Ji-Jun
, p. 4476 - 4480 (2008/02/09)
A variety of N-acetyl-β-aryl-1,2-didehydroethylamines were synthesized by direct reduction-acetylation of β-aryl-nitroolefins and assayed as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the first time. Compound 7a exhibited a TI value of >13.2 with CC50 value of >0.787 mM in C8166 cells. This structure-activity relationship (SAR) study provided a new lead for design and discovery of more potent and selective analogues act as NNRTIs.
