95062-66-1Relevant academic research and scientific papers
Silver-catalyzed Double Decarboxylative Radical Alkynylation/Annulation of Arylpropiolic Acids with α-keto Acids: Access to Ynones and Flavones under Mild Conditions
Meng, Mengting,Wang, Guofang,Yang, Liangfeng,Cheng, Kai,Qi, Chenze
supporting information, p. 1218 - 1231 (2018/02/16)
Ynones are privileged building blocks in various organic syntheses of heterocyclic derivatives due to their multifunctional nature, and flavones are an important class of natural products with a wide range of biological activities. We describe the catalytic double decarboxylative alkynylation of arylpropiolic acids with α-keto acids. With Ag(I)/persulfate as the catalysis system, the valuable ynones bearing various substituents could be easily obtained. The introduction of hydroxyl substituent on ortho-site of α-keto acids make this strategy further applicable to the construction of flavone derivatives via heteroannulation in moderate to good yields with a similar silver-catalyzed system. The reactions proceed under relatively mild reaction conditions and tolerate a wide variety of functional groups. Control experiments indicated that both the reactions undergo radical processes. (Figure presented.).
Unusual Friedel-Crafts Reactions. Part 8. Synthesis of 2-Hydroxyarylglyoxylic Acids via ortho-Specific Oxaloylation of Phenols with Oxalyl Chloride
Bigi, Franca,Casiraghi, Giovanni,Casnati, Giuseppe,Sartori, Giovanni
, p. 2655 - 2657 (2007/10/02)
2-Hydroxyarylglyoxylic acids (6) are readily prepared from the bromomagnesium salts of phenols (2) and oxalyl chloride (3) in toluene at room temperature.This procedure bypasses some of the inherent difficulties in the conventional Friedel-Crafts acylatio
