950651-07-7

Upstream product

• 144789-73-1 2-amino-2-[4-(trifluoromethyl)phenyl]acetic acid 
• 390815-48-2 methyl 2-amino-2-[4-(trifluoromethyl)phenyl]acetate hydrochloride 
• 203065-99-0 2-amino-2-(4-(trifluoromethyl)phenyl)acetamide 
• 108-94-1 cyclohexanone 

Downstream Products

• 950651-08-8 ethyl {2-oxo-3-[4-(trifluoromethyl)phenyl]-1,4-diazaspiro[4.5]dec-3-en-1-yl}acetate 

Relevant academic research and scientific papers

GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

Compounds of formula (I) or a salt thereof are provided wherein R1, R2, R6, R7, R8, R9 and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture

COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF

Compounds of formula (I) and salts and solvates thereof are provided: wherein R1 to R8 and n are defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.

1-(2-ARYL-2-OXOETHYL)-3-PHENYL-1, 4-DIAZASPIRO [4.5]DEC-3-EN-2-ONE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS

Novel acetophenone compounds of formula (I), compositions containing (I), processes for the preparation of (I), and use of (I) as inhibitors of the glycine transporter, are provided. Definitions of Ar, R5, R6, R7, R8