390815-48-2

Usage

Uses

Used in Pharmaceutical Industry:
Methyl amino[4-(trifluoromethyl)phenyl]acetate hydrochloride is used as a pharmaceutical intermediate for the synthesis of various drugs, including anticonvulsants and antiviral agents. Its unique chemical structure and properties contribute to the development of new chemical entities for medicinal purposes.
Used in Drug Synthesis:
Methyl amino[4-(trifluoromethyl)phenyl]acetate hydrochloride is used as a key building block in the synthesis of complex drug molecules. Its reactivity and solubility in both water and organic solvents make it suitable for use in various chemical reactions, facilitating the production of pharmaceutical compounds with desired therapeutic effects.
Used in Medicinal Chemistry Research:
Methyl amino[4-(trifluoromethyl)phenyl]acetate hydrochloride is utilized in medicinal chemistry research to explore its potential as a precursor for the development of new drugs. Its unique structure and properties can be further modified and optimized to enhance its therapeutic potential and selectivity, leading to the discovery of novel pharmaceutical agents.

InChI:InChI=1/C10H10F3NO2.ClH/c1-16-9(15)8(14)6-2-4-7(5-3-6)10(11,12)13;/h2-5,8H,14H2,1H3;1H

Upstream product

• 67-56-1 methanol 
• 144789-73-1 2-amino-2-[4-(trifluoromethyl)phenyl]acetic acid 

Downstream Products

• 950651-37-3 ethyl {2-oxo-3-[4-(trifluoromethyl)phenyl]-1,4-diazaspiro[4.4]non-3-en-1-yl}acetate 
• 950651-38-4 {2-oxo-3-[4-(trifluoromethyl)phenyl]-1,4-diazaspiro[4.4]non-3-en-1-yl}acetic acid 
• 950651-07-7 3-[4-(trifluoromethyl)phenyl]-1,4-diazaspiro[4.5]dec-3-en-2-one 
• 203065-99-0 2-amino-2-(4-(trifluoromethyl)phenyl)acetamide 

Relevant academic research and scientific papers

Triple role of phenylselenonyl group enabled a one-pot synthesis of 1,3-oxazinan-2-ones from α-isocyanoacetates, phenyl vinyl selenones, and water

Reaction of α-substituted α-isocyanoacetates with phenyl vinyl selenones in the presence of a catalytic amount of base (DBU or Et3N, 0.05-0.1 equiv) followed by addition of p-toluenesulfonic acid (PTSA, 0.1-0.2 equiv) afforded 4,4,5-trisubstituted 1,3-oxazinan-2-ones in good to excellent yields. Enantiomerically enriched heterocycles can also be prepared using a Cinchona alkaloid-derived bifunctional organocatalyst for the Michael addition step. The phenylselenonyl group served as an activator for the Michael addition, a leaving group and a latent oxidant in this integrated reaction sequence.

GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

Compounds of formula (I) or a salt thereof are provided wherein R1, R2, R6, R7, R8, R9 and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture

COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF

Compounds of formula (I) and salts and solvates thereof are provided: wherein R1 to R8 and n are defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.

1-(2-ARYL-2-OXOETHYL)-3-PHENYL-1, 4-DIAZASPIRO [4.5]DEC-3-EN-2-ONE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS

Novel acetophenone compounds of formula (I), compositions containing (I), processes for the preparation of (I), and use of (I) as inhibitors of the glycine transporter, are provided. Definitions of Ar, R5, R6, R7, R8