390815-48-2

Basic information

• Product Name: Methyl amino[4-(trifluoromethyl)phenyl]acetate hydrochloride
• Synonyms: Methyl amino[4-(trifluoromethyl)phenyl]acetate hydrochloride;Methyl 2-amino-2-[4-(trifluoromethyl)phenyl]acetate hydrochloride;4-(Trifluoromethyl)-DL-phenylglycine methyl ester hydrochloride;Methyl amino[4-(trifluoromethyl)phenyl]acetate hydrochloride, 4-(1-Amino-2-methoxy-2-oxoethyl)benzotrifluoride hydrochloride;METHYL 2-AMINO-2-[4-(TRIFLUOROMETHYL)PHENYL]ACETATE HCL
• CAS NO: 390815-48-2
• Molecular Formula: C₁₀H₁₀F₃NO₂*ClH
• Molecular Weight: 269.65
• Mol File: 390815-48-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl amino[4-(trifluoromethyl)phenyl]acetate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl amino[4-(trifluoromethyl)phenyl]acetate hydrochloride(390815-48-2)
• EPA Substance Registry System: Methyl amino[4-(trifluoromethyl)phenyl]acetate hydrochloride(390815-48-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 390815-48-2(Hazardous Substances Data)

Usage

General Description

Methyl amino[4-(trifluoromethyl)phenyl]acetate hydrochloride is a chemical compound with the molecular formula C10H12F3NO2·HCl. It is a hydrochloride salt of the methyl ester of 4-(trifluoromethyl)phenylglycine, which is an amino acid derivative. Methyl amino[4-(trifluoromethyl)phenyl]acetate hydrochloride is commonly used as a pharmaceutical intermediate in the synthesis of various drugs, including anticonvulsants and antiviral agents. It is also utilized in the development of new chemical entities for medicinal purposes. Methyl amino[4-(trifluoromethyl)phenyl]acetate hydrochloride is a white to off-white crystalline powder that is soluble in water and organic solvents, making it suitable for use in various chemical reactions and processes.

InChI:InChI=1/C10H10F3NO2.ClH/c1-16-9(15)8(14)6-2-4-7(5-3-6)10(11,12)13;/h2-5,8H,14H2,1H3;1H

Upstream product

• 67-56-1 methanol 
• 144789-73-1 2-amino-2-[4-(trifluoromethyl)phenyl]acetic acid 

Downstream Products

• 950651-37-3 ethyl {2-oxo-3-[4-(trifluoromethyl)phenyl]-1,4-diazaspiro[4.4]non-3-en-1-yl}acetate 
• 950651-38-4 {2-oxo-3-[4-(trifluoromethyl)phenyl]-1,4-diazaspiro[4.4]non-3-en-1-yl}acetic acid 
• 950651-07-7 3-[4-(trifluoromethyl)phenyl]-1,4-diazaspiro[4.5]dec-3-en-2-one 
• 203065-99-0 2-amino-2-(4-(trifluoromethyl)phenyl)acetamide 

Relevant articles and documents

Triple role of phenylselenonyl group enabled a one-pot synthesis of 1,3-oxazinan-2-ones from α-isocyanoacetates, phenyl vinyl selenones, and water

Reaction of α-substituted α-isocyanoacetates with phenyl vinyl selenones in the presence of a catalytic amount of base (DBU or Et3N, 0.05-0.1 equiv) followed by addition of p-toluenesulfonic acid (PTSA, 0.1-0.2 equiv) afforded 4,4,5-trisubstituted 1,3-oxazinan-2-ones in good to excellent yields. Enantiomerically enriched heterocycles can also be prepared using a Cinchona alkaloid-derived bifunctional organocatalyst for the Michael addition step. The phenylselenonyl group served as an activator for the Michael addition, a leaving group and a latent oxidant in this integrated reaction sequence.

COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF

Compounds of formula (I) and salts and solvates thereof are provided: wherein R1 to R8 and n are defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.