95066-29-8

Upstream product

• 91652-76-5 1-benzyl 4-azido-4-deoxy-2,3-O-isopropylidene-α-D-mannopyranoside 
• 114894-82-5 benzyl 6-O-tetra-butyldiphenylsilyl-α-D-mannopyranoside 
• 3458-28-4 D-Mannose 
• 15548-45-5 (2S,3S,4S,5S,6R)-2-benzyloxy-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol 
• 100-51-6 benzyl alcohol 
• 91652-73-2 Trifluoro-methanesulfonic acid (3aS,4S,6R,7S,7aR)-4-benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester 
• 91652-74-3 benzyl 4-azido-6-O-tert-butyldiphenylsilyl-4-deoxy-2,3-O-isopropylidene-α-D-mannopyranoside 
• 114912-50-4 (3aS,4S,6R,7aR)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-dihydro-[1,3]dioxolo[4,5-c]pyran-7-one 
• 91652-71-0 benzyl 6-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-α-D-mannopyranoside 
• 91652-72-1 benzyl 6-O-tert-butyldiphenylsilyl-2,3-O-isopropylidene-α-D-talopyranoside 

Downstream Products

• 114894-83-6 benzyl 4-benzyloxycarbonylamino-4-deoxy-2,3-O-isopropylidene-α-D-mannopyranoside 
• 114894-84-7 benzyl 4-benzyloxycarbonylamino-4,6,7-trideoxy-6-ene-2,3-O-isopropylidene-α-D-manno-octadialdopyranoside 
• 114894-87-0 ((3aS,4S,6S,7S,7aS)-4-Benzyloxy-6-formyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-carbamic acid benzyl ester 
• 114894-86-9 (3aS,4S,5aR,9aR,9bS)-4-Benzyloxy-2,2,9-trimethyl-octahydro-[1,3]dioxolo[4',5':4,5]pyrano[3,2-b]pyridine 
• 91652-64-1 (1R,3S,4S,5S,6R)-7-aza-3-benzyloxy-4,5-isopropylidenedioxy-2-oxa-bicyclo<4,4,0>-decane 
• 85624-09-5 (3aR,9R,9aR,9bS)-octahydro-2,2-dimethyl-[1,3]dioxolo[4,5-a]indolizin-9-ol 
• 72741-87-8 swainsonine 
• 155688-59-8 benzoyl 6-azido-4-(N-(tert-butoxycarbonyl)amino)-4,6-dideoxy-2,3-O-isopropylidene-D-mannopyranoside 
• 155688-58-7 benzyl 6-azido-4-(N-(tert-butoxycarbonyl)amino)-4,6-dideoxy-2,3-O-isopropylidene-D-mannopyranoside 
• 155688-57-6 benzyl 4-(N-(tert-butoxycarbonyl)amino)-4-deoxy-2,3-O-isopropylidene-6-O-methane-sulfonyl-D-mannopyranoside 
• 95189-02-9 1,4-dideoxy-1,4-imino-D-mannitol 
• 155688-56-5 benzyl 4-(N-(tert-butoxycarbonyl)amino)-4-deoxy-2,3-O-isopropylidene-D-mannopyranoside 

Relevant academic research and scientific papers

Design Synthesis and Preliminary Evaluation of a Potent &α-Mannosidase Inhibitor: 1,4-Dideoxy-1,4-imino-D-mannitol

1,4-Dideoxy-1,4-imino-D-mannitol (1), synthesised from benzyl α-D-mannopyranoside, is a potent competitive inhibitor of the hydrolysis of p-nitrophenyl α-D-mannopyranoside catalysed by Jack Bean α-mannosidase (Canavalia ensiformis); this is the first repo

3, 5, and/or 6 substituted analogues of swainsonine processes for their preparation and their use as therapeutic agents

The invention relates to novel 3, 5, and/or 6 swainsonine analogues, processes for their preparation and their use as therapeutic agents. The invention also relates to pharmaceutical compositions containing the compounds and their use as therapeutics.

SYNTHESIS OF THE α-MANNOSIDASE INHIBITORS SWAINSONINE AND 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL FROM MANNOSE

4-azido-4-deoxy-2,3-O-isopropylidene-α-D-mannopyranoside is a key intermediate in the syntheses of the α-mannosidase inhibitors, swainsonine and 1,4-dideoxy-1,4-imino-D-mannitol, and of the α-galactosidase inhibitor 1,4-dideoxy-1,4-imino-D-lyxitol, from mannose.