950668-34-5Relevant articles and documents
Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity
Wang, Xiangdong Alan,Cianci, Christopher W.,Yu, Kuo-Long,Combrink, Keith D.,Thuring, Jan W.,Zhang, Yi,Civiello, Rita L.,Kadow, Kathleen F.,Roach, Julia,Li, Zhufang,Langley, David R.,Krystal, Mark,Meanwell, Nicholas A.
, p. 4592 - 4598 (2008/02/11)
Extensive SAR studies and optimization of ADME properties of benzimidazol-2-one derivatives led to the identification of BMS-433771 (3) as an orally active RSV fusion inhibitor. In order to extend the structure-activity relationships for this compound ser