950674-80-3

Upstream product

• 950674-72-3 5-(4-fluorophenyl)-7-isopropyl-4-oxo-3,4-dihydrospiro[chromen-2,1'-cyclobutane]-6-carbaldehyde 
• 169222-42-8 (4-(trifluoromethoxy)-phenyl)magnesium bromide 

Downstream Products

• 950674-81-4 5-(4-fluorophenyl)-6-{fluoro[4-(trifluoromethoxy)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one 
• 950674-82-5 5-(4-fluorophenyl)-7-isopropyl-6-[4-(trifluoromethoxy)benzoyl]spiro[chromen-2,1'-cyclobutan]-4(3H)-one 
• 950673-97-9 (4S)-5-(4-fluorophenyl)-6-{(R)-hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropyl-3,4-di-hydrospiro[chromen-2,1'-cyclobutan]-4-ol 
• 950673-96-8 (4S)-5-(4-fluorophenyl)-6-{(S)-hydroxy[4-(trifluoromethoxy)phenyl]methyl}-7-isopropyl-3,4-di-hydrospiro[chromen-2,1'-cyclobutan]-4-ol 

Relevant academic research and scientific papers

Chromanol derivatives - A novel class of CETP inhibitors

Based on our former development candidate BAY 38-1315, optimization efforts led to the discovery of a novel chemical class of orally active cholesteryl ester transfer protein (CETP) inhibitors. The chromanol derivative 19b is a highly potent CETP inhibitor with favorable pharmacokinetic properties suitable for clinical studies. Chemical process optimization furnished a robust synthesis for a kilogram-scale process.

Substituted Chromanol Derivatives and Their Use

The present invention relates to substituted chromanol derivatives, to processes for their preparation, to their use on their own or in combination for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatmen