95068-31-8Relevant academic research and scientific papers
Conversion of 3-arylphthalides into anthrones with a methylcarbonyl substituent at the C-10 position
Bieniek, Adam,Bartczak, Monika M.,Epsztajn, Jan
scheme or table, p. 151 - 153 (2009/10/15)
The ortho-lithiation of a benzoic acid anilide followed by condensation with an aryl aldehyde gave a 3-arylphthalide. Reductive alkylation with 1-methoxy-1-trimethylsilyloxyethene gave a substituted aromatic carboxylic acid which was cyclised to an anthro
Application of organolithium and related reagents in synthesis, part 31: Effective conversion of 3-arylphthalides into 2-(1-aryl-3-oxo-4- alkoxycarbonylbutyl) benzoic acids
Bieniek, Adam,Kulikiewicz, Krystyna K.,Bartczak, Monika M.
, p. 3249 - 3259 (2007/10/03)
A convenient three-step protocol preparation of the ortho-alkylated (longchain substituent with terminal methylcarbonyl or acetoacetate moiety) aromatic carboxylic acids 15 or 16 from benzoic acids anilides 10 was developed, which exploited the reductive
Application of organolithium and related reagents in synthesis. XXVII.[1] Effect of the nucleophilic character of silyl enol ethers upon the conversion of 3-arylphthalides into 2-(1-Aryl-2-methoxycarbonyl) benzoic acids
Bieniek, Adam,Epsztajn, Jan,Kulikiewicz, Krystyna K.
, p. 667 - 677 (2007/10/03)
A convenient two step protocol preparation of the ortho-alkylated (by secondary substituent with the carbomethoxy group at the end of alkyl chain) aromatic carboxylic acids 6 from benzoic acids anilides 1 was developed, which exploited the reductive alkylation of phthalides 4 with silyl vinyl ethers 5a-b or silyl ketene acetals 5c-g as a key step, is described.
Application of organolithium and related reagents in synthesis, Part 24.1 Synthetic strategies based on aromatic metallation. A concise regiospecific conversion of benzoic acids into 2-(1-aryl-2-methoxycarbonylethyl)benzoic acids
Epsztajn,Bieniek,Kowalska,Kulikiewicz
, p. 1603 - 1607 (2007/10/03)
The synthesis of the 3-arylphthalides 3 via metallation (BuLi) of the benzanilides 1 and subsequent reaction of the generated bis-lithiated anilides 2 with aromatic aldehydes is described. Conversion of 3 into the corresponding 2-(1-aryl-2-methoxycarbonylethyl)benzoic acids 4 by treatment with 1-methoxy-1-trimethylosiloxyethene in the presence of titanium tetrachloride, as a way of regiospecific transformation of benzoic acids, is also described.
