950755-36-9Relevant academic research and scientific papers
Development of a novel nucleoside analogue with S-type sugar conformation: 2′-deoxy-trans-3′,4′-bridged nucleic acids
Osaki, Tomohisa,Obika, Satoshi,Harada, Yasuki,Mitsuoka, Yasunori,Sugaya, Kensaku,Sekiguchi, Mitsuaki,Roongjang, Somjing,Imanishi, Takeshi
, p. 8977 - 8986 (2008/02/10)
Two novel trans-3′,4′-bridged nucleic acid (trans-3′,4′-BNA) monomers, one with a 3,5,8-trioxabicyclo[5.3.0]decane structure and the other with a 4,7-dioxabicyclo[4.3.0]nonane structure, were successfully synthesized from thymidine. The locked trans-fused ring structures of the nucleoside analogues were confirmed by X-ray crystallography, which also indicated that their furanose rings had a typical S-type conformation involving C2′-endo or C3′-exo sugar puckering, respectively, and the same ring conformation as that observed in the B-type helical structure of the DNA duplex.
Synthesis of novel 2′-deoxy type trans-3′,4′-bridged nucleic acid
Osaki, Tomohisa,Obika, Satoshi,Harada, Yasuki,Mitsuoka, Yasunori,Sugaya, Kensaku,Sekiguchi, Mitsuaki,Roongjang, Somjing,Imanishi, Takeshi
, p. 1079 - 1082 (2008/09/17)
We newly designed and synthesized a 2 ′-deoxy type trans-3′,4′-bridged nucleic acid (trans-3′,4′-BNA) analogues bearing a 4,7-dioxabicyclo[4.3.0]nonane structure. The synthesis of the trans-3′,4′-BNA was carried out successfully from thymidine over 21 ste
