950785-27-0

Basic information

• Product Name: 1-[(4-iodophenyl)methyl]-2-pyrrolidinone
• Synonyms: 1-[(4-iodophenyl)methyl]-2-pyrrolidinone
• CAS NO: 950785-27-0
• Molecular Weight: 301.127
• Mol File: 950785-27-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-[(4-iodophenyl)methyl]-2-pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-iodophenyl)methyl]-2-pyrrolidinone(950785-27-0)
• EPA Substance Registry System: 1-[(4-iodophenyl)methyl]-2-pyrrolidinone(950785-27-0)

Safety Data

• Hazardous Substances Data: 950785-27-0(Hazardous Substances Data)

Upstream product

• 616-45-5 2-pyrrolidinon 
• 16004-15-2 1-bromomethyl-4-iodobenzene 

Downstream Products

• 1092459-32-9 1-({4-[3-(trifluoromethyl)-1H-indazol-1-yl]phenyl}methyl)-2-pyrrolidinone 
• 1092459-37-4 1-({4-[5-(methylamino)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]phenyl}methyl)-2-pyrrolidinone 
• 1092459-29-4 1-({4-[5-hydroxy-3-(trifluoromethyl)-1H-indazol-1-yl]phenyl}methyl)-2-pyrrolidinone 
• 1092464-47-5 1-({4-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}methyl)-2-pyrrolidinone 
• 1092464-44-2 1-({4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}methyl)-2-pyrrolidinone 
• 1092459-31-8 1-{4-[(2-oxo-1-pyrrolidinyl)methyl]phenyl}-3-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-indazol-5-one 
• 1022930-55-7 1-({4-[5-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone 
• 1022930-67-1 1-({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone 
• 1022930-40-0 1-({4-[6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone 
• 1022930-44-4 1-({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone 
• 1022930-33-1 1-({4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]phenyl}methyl)-2-pyrrolidinone 
• 1022930-38-6 1-({4-[3-(trifluoromethyl)-4,7-dihydropyrano[3,4-c]pyrazol-1(5H)-yl]phenyl}methyl)-2-pyrrolidinone 

Relevant articles and documents

AMPA RECEPTOR POTENTIATORS

The invention provides compounds of the formula (I): wherein R1 and R2 are defined in the specification, to pharmaceutical compositions comprising the compounds and the compounds for use as medicaments. The compounds potentiate AMPA receptor function and are expected to be useful in the treatment of central nervous system disorders, for example in the treatment of depressive disorders, mood disorders and cognitive dysfunction associated with neuropsychiatric disorders such as schizophrenia.

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE

Compounds of formula (I), and salts and solvates thereof are provided: Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEROF IN MEDICINE

Compound of formula (I) and salts thereof are provided: wherein X, Y, Z, R1, R2 and R3 are as defined in the specification. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.