950820-05-0Relevant academic research and scientific papers
Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a cellular environment
Weinstein, David S.,Liu, Wen,Ngu, Khehyong,Langevine, Charles,Combs, Donald W.,Zhuang, Shaobin,Chen, Cindy,Madsen, Cort S.,Harper, Timothy W.,Robl, Jeffrey A.
, p. 5115 - 5120 (2008/12/20)
A series of 2,4,5-tri-substituted imidazoles has proven to be highly potent in inhibiting mammalian 15-lipoxygenase (15-LO) with excellent selectivity over human isozymes 5- and P-12-LO. Non-symmetrical sulfamides (e.g., 21a-n) were found to be suitable r
