950846-26-1Relevant articles and documents
5-HT2A AGONISTS FOR USE IN TREATMENT OF DEPRESSION
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Paragraph 0438, (2021/05/14)
The present invention relates to agonists of the 5-HT2A serotonin receptors and their medical uses. In one aspect the invention relates to 5-HT2A agonists of formula (I). In second aspect, the invention relates to selective 5-HT2A agonists of formula (II). In another aspect, the invention relates to mixed 5-HT2A/5-HT2C agonists of formula (III). In yet another aspect, the invention relates to 5-HT2A agonists for use in the treatment of a depressive disorder, more particular a 5-HT2A agonist for the use in the treatment of treatment-resistant depression.
Side functionalization of diboronic acid precursors for covalent organic frameworks
Faury, Thomas,Dumur, Frederic,Clair, Sylvain,Abel, Mathieu,Porte, Louis,Gigmes, Didier
, p. 2067 - 2075 (2013/04/23)
A series of substituted 1,4-benzenediboronic acids (BDBA) was synthesized and their thermal properties investigated. Two diboronic acids were studied as building-blocks for covalent organic framework (COF) formation, namely 2,5-dimethoxy-1,4-benzenediboronic acid and 2-nitro-1,4-benzeneboronic acid. Interestingly, substitution of the BDBA core caused a dramatic decrease of the polymerization temperature leading to the formation of a less organized structure.
Aryl trihydroxyborate salts: Thermally unstable species with unusual gelation abilities
Moy, Cheryl L.,Kaliappan, Raja,McNeil, Anne J.
, p. 8501 - 8507 (2011/12/04)
A series of aryl trihydroxyborate salts were synthesized and found to form gels in benzene. The compounds were thermally unstable and readily underwent protodeboronation in solution and the solid state. Gelation could be induced without decomposition via sonication. Subsequent characterization studies revealed an unusual dependence of gel properties on alkyl chain length.
2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER
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Page/Page column 118-119, (2008/12/08)
The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors.
Synthesis of penta-p-phenylenes with oligo(ethylene glycol) side chains
López-Romero, J. Manuel,Rico, Rodrigo,Martínez-Mallorquín, Rocío,Hierrezuelo, Jesús,Guillén, Elena,Cai, Chengzhi,Otero, J. Carlos,López-Tocón, Isabel
, p. 6075 - 6079 (2008/03/12)
We report an efficient synthesis of a series of penta-p-phenylene derivatives with four side chains of various lengths, including deca(ethylene glycol) groups. The key feature of the synthesis is that the side chains are efficiently introduced in the last step, facilitating optimization of the side chains for different applications. Raman spectroscopy study indicates a similarly high rigidity for all these compounds, even those with long oligo(ethylene glycol) side chains. The deca(ethylene glycol)-substituted penta-p-phenylene derivatives are versatile building blocks for construction of nanometric, tripod-shaped adsorbates for biological applications.