(4-Bromo-2,5-dimethoxyphenyl)boronic acid

Base Information

• Chemical Name: (4-Bromo-2,5-dimethoxyphenyl)boronic acid
• CAS No.: 950846-26-1
• Molecular Formula: C₈H₁₀BBrO₄
• Molecular Weight: 260.88
• Hs Code.: 2931900090
• Mol file: 950846-26-1.mol

Synonyms:4-BROMO-2,5-DIMETHOXYPHENYLBORONIC ACID;

Chemical Property of (4-Bromo-2,5-dimethoxyphenyl)boronic acid

Chemical Property:

• PSA: 58.92000
• LogP: 0.14610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2,5-dimethoxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-Bromo-2,5-dimethoxyphenyl)boronic acid

There total 7 articles about (4-Bromo-2,5-dimethoxyphenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Trimethyl borate (121-43-7,63156-11-6) + 1,4-dibromo-2,5-dimethoxybenzene (2674-34-2) → (4-bromo-2,5-dimethoxyphenyl)boronic acid (950846-26-1)

Guidance literature:

1,4-dibromo-2,5-dimethoxybenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

Trimethyl borate; In tetrahydrofuran;

With hydrogenchloride; Further stages.;

DOI:10.1016/j.tetlet.2007.06.167

Reference yield: 63.0%

1,4-dibromo-2,5-dimethoxybenzene (2674-34-2) → (4-bromo-2,5-dimethoxyphenyl)boronic acid (950846-26-1)

Guidance literature:

1,4-dibromo-2,5-dimethoxybenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

With Triisopropyl borate; In tetrahydrofuran; at -78 - 20 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃; for 0.333333h;

DOI:10.1021/jo201353j

Reference yield:

Triisopropyl borate (5419-55-6) + 1,4-dibromo-2,5-dimethoxybenzene (2674-34-2) → (4-bromo-2,5-dimethoxyphenyl)boronic acid (950846-26-1)

Guidance literature:

1,4-dibromo-2,5-dimethoxybenzene; With n-butyllithium; at -78 ℃; for 0.333333h; Inert atmosphere;

Triisopropyl borate; at -78 - 20 ℃; for 20h; Inert atmosphere;

upstream raw materials:

Trimethyl borate

1,4-dibromo-2,5-dimethoxybenzene

1,4-dimethoxybezene

Triisopropyl borate

Refernces

• 1、 Faury, Thomas,Dumur, Frederic,Clair, Sylvain,Abel, Mathieu,Porte, Louis,Gigmes, Didier. "Side functionalization of diboronic acid precursors for covalent organic frameworks". . p. 2067 - 2075. Retrieved 2013/04/23.
• 2、 -. "2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER". Page/Page column 118-119. . Retrieved 2008/12/08.