950857-36-0

Upstream product

• 694479-56-6 6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxylic acid 
• 98-16-8 3-trifluoromethylaniline 
• 106109-76-6 methyl 3-oxo-3-(3-(trifluoromethyl)phenylamino)propanoate 

Downstream Products

• 1281969-58-1 N-[3-(dimethylamino)propyl]-5-iodo-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 
• 1281969-57-0 3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium benzenesulfonate 
• 1281969-55-8 5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-N-(3-(dimethylamino)propyl)-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 
• 1281969-54-7 3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium bromide 
• 1281969-56-9 3-(5-(1-(4-cyanophenyl)-1H-pyrazol-5-yl)-6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamido)-N,N,N-trimethylpropan-1-aminium acetate 
• 950857-41-7 C₂₄H₂₂F₃NO₅S 
• 950857-98-4 C₂₀H₁₄F₃N₃O₄S 
• 950857-50-8 C₂₀H₁₂F₃N₃O₃S 
• 950857-47-3 C₂₁H₁₄F₃N₃O₃S 
• 950857-59-7 C₂₂H₁₅F₃N₂O₃S 
• 950857-44-0 C₁₅H₁₂F₃NO₃S 
• 950857-76-8 C₁₅H₉F₃N₂O₃ 
• 950857-38-2 C₁₅H₁₁F₃INO₃ 

Relevant academic research and scientific papers

ELASTASE INHIBITORS

Described herein are compounds, compositions, and methods of their use for the treatment of a lung or intestinal disease.

Novel 2-Pyridone Compounds

The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R7, L, X and Y are as defined in the specification; together with processes and intermediates for their preparation,

NOVEL SALT 628

6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-{[5-(methylsulfonyl)pyridin-2-yl]methyl}-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 4-methylbenzenesulfonate and a novel crystalline form thereof are disclosed together with processes for preparing such salt and form, pharmaceutical compositions comprising such a salt and form, and the methods of treatment using such a salt and form.

DIMERS OF 5- [ (4-CYANOPHENYL) SULFINYL] -6-METHYL-2-OXO-1- [3- (TRIFLUOROMETHYL)PHENYL] -1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE FOR TREATING RESPIRATORY DISEASES

Six specific compounds having human neutrophil elastase inhibitory activity are disclosed, one of which has the structural formula wherein A- is a pharmaceutically acceptable anion. The compounds are useful inter alia for the treatment of infla

MULTIMERS QF HETEROCYCLIC COMPOUNDS AND THEIR USE

Covalent conjugates of two or more compounds, each having a structure as defined in any of WO2004/043924, WO2005/021509, WO2005/021512, WO2005/026123, WO2005/026124, WO2006/098683 and WO2006/098684, are inhibitors of human neutrophil elastase, useful in t

2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE

The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and X are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptab