950858-65-8

Basic information

• Product Name: 1-tert-butyl-1H-pyrazole-4-carboxylic acid
• Synonyms: 1-tert-butyl-1H-pyrazole-4-carboxylic acid;1-tert-butylpyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 1-(1,1-dimethylethyl)-
• CAS NO: 950858-65-8
• Molecular Formula: C₈H₁₂N₂O₂
• Molecular Weight: 168.195
• Mol File: 950858-65-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 306.2±15.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.91±0.10(Predicted)
• CAS DataBase Reference: 1-tert-butyl-1H-pyrazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butyl-1H-pyrazole-4-carboxylic acid(950858-65-8)
• EPA Substance Registry System: 1-tert-butyl-1H-pyrazole-4-carboxylic acid(950858-65-8)

Safety Data

• Hazardous Substances Data: 950858-65-8(Hazardous Substances Data)

Usage

General Description

1-tert-butyl-1H-pyrazole-4-carboxylic acid is a chemical compound with the molecular formula C8H12N2O2. It is an organic compound that belongs to the class of pyrazole carboxylic acids. 1-tert-butyl-1H-pyrazole-4-carboxylic acid is commonly used in the synthesis of other chemical compounds and pharmaceuticals. It is also known for its potential biological activities and therapeutic applications. Its structure includes a tert-butyl group attached to the carbon atom of the pyrazole ring, and a carboxylic acid group attached to the fourth carbon atom of the pyrazole ring. This chemical compound is of interest to researchers and chemists due to its diverse applications and potential in drug development and materials science.

Upstream product

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Relevant articles and documents

KDM5 INHIBITORS

The present invention provides a compound of Formula (I) (represented as tautomers Ia and Ib): (I) or the pharmaceutically acceptable salts thereof, which are KDM5 inhibitors.

KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferrably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.