950858-65-8

Usage

Uses

Used in Pharmaceutical Synthesis:
1-tert-butyl-1H-pyrazole-4-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex molecular structures, enhancing the development of new drugs with potential therapeutic properties.
Used in Drug Development:
1-tert-butyl-1H-pyrazole-4-carboxylic acid is used as a building block in drug development for its potential biological activities, contributing to the creation of compounds with therapeutic applications in treating various diseases and conditions.
Used in Materials Science:
1-tert-butyl-1H-pyrazole-4-carboxylic acid is used as a component in the development of new materials, leveraging its chemical properties to improve material characteristics such as stability, reactivity, or other functional attributes in various industrial applications.

Upstream product

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• 37622-90-5 4-ethoxycarbonylpyrazole 
• 75-65-0 tert-butyl alcohol 
• 80370-42-9 ethyl 2-formyl-3-oxopropanoate 
• 7400-27-3 tertbutylhydrazine hydrochloride 
• 70951-85-8 4-bromo-1-(1,1-dimethylethyl)-1H-pyrazole 

Relevant academic research and scientific papers

KDM5 INHIBITORS

The present invention provides a compound of Formula (I) (represented as tautomers Ia and Ib): (I) or the pharmaceutically acceptable salts thereof, which are KDM5 inhibitors.

KDM5 INHIBITORS

The present invention provides a compound of Formula (I) (represented as tautomers Ia and Ib) or the pharmaceutically acceptable salts thereof, which are KDM5 inhibitors.

KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferrably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

CHEMICAL COMPOUNDS

The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

Adamantyl-pyrazole carboxamides as inhibitors of 11B-hydroxysteroid dehydrogenase

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.