950895-48-4Relevant academic research and scientific papers
Synthesis and preliminary anti-HIV activities of andrographolide derivatives
Wang, Bin,Ge, Liang,Huang, Wenlong,Zhang, Huibin,Qian, Hai,Li, Jing,Zheng, Yongtang
, p. 252 - 258 (2011/09/20)
Recent studies indicated that andrographolide was a potential anti-HIV therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their anti-HIV activities were evaluated in vitro. As compared with TI, comp
Synthesis of andrographolide derivatives and their TNF-α and IL-6 expression inhibitory activities
Li, Jing,Huang, Wenlong,Zhang, Huibin,Wang, Xinyang,Zhou, Huiping
, p. 6891 - 6894 (2008/09/16)
The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on TNF-α and IL-6 secretion in mouse macrophages were also evaluated. Most of the tested compounds showed inhibitory effects, and the compounds with the structure of 12-hydroxy-14-dehydroandrographolide showed better inhibitory activity than the compounds with the structure of isoandrographolide.
