95095-84-4

Basic information

• Product Name: 3-Amino-6-chloropyridine-2-carbonitrile
• Synonyms: 3-Amino-6-chloro-2-cyanopyridine;3-aMino-6-chloropicolinonitrile;3-Amino-6-chloro-2-cyanopyridine, 3-Amino-6-chloropicolinonitrile
• CAS NO: 95095-84-4
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.57
• Product Categories: Amines;Pyridines
• Mol File: 95095-84-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 175-176.5 °C(Solv: ethanol (64-17-5))
• Boiling Point: 372.4 °C at 760 mmHg
• Flash Point: 179 °C
• Appearance: /
• Density: 1.427 g/cm³
• Vapor Pressure: 9.67E-06mmHg at 25°C
• Refractive Index: 1.615
• PKA: -0.85±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-6-chloropyridine-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-6-chloropyridine-2-carbonitrile(95095-84-4)
• EPA Substance Registry System: 3-Amino-6-chloropyridine-2-carbonitrile(95095-84-4)

Safety Data

• Hazardous Substances Data: 95095-84-4(Hazardous Substances Data)

Usage

General Description

3-Amino-6-chloropyridine-2-carbonitrile is a chemical compound with the molecular formula C6H4ClN3. It is a cyanopyridine derivative with a 3-amino and 6-chloro substitution on the pyridine ring. 3-Amino-6-chloropyridine-2-carbonitrile is used in organic synthesis as a building block for the production of various pharmaceuticals and agrochemicals. It has also been studied for its potential antifungal and antiviral properties. In addition, 3-Amino-6-chloropyridine-2-carbonitrile is used as a starting material for the preparation of heterocyclic compounds and is important in the development of new materials and chemical processes.

InChI:InChI=1/C6H4ClN3/c7-6-2-1-4(9)5(3-8)10-6/h1-2H,9H2

Upstream product

• 93683-65-9 6-chloro-3-nitropicolinonitrile 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 7439-89-6 iron 
• 2402-78-0 2,6-dichloropyridine 

Downstream Products

• 93684-07-2 6-chloropyrido[3,2-d]pyrimidine-2,4-diamine 
• 216167-07-6 6-(4-Methoxy-phenylsulfanyl)-pyrido[3,2-d]pyrimidine-2,4-diamine 
• 216167-06-5 6-(2-Methoxy-phenylsulfanyl)-pyrido[3,2-d]pyrimidine-2,4-diamine 
• 216167-08-7 6-(3,4-Dimethoxy-phenylsulfanyl)-pyrido[3,2-d]pyrimidine-2,4-diamine 
• 95095-96-8 6-<(4-Fluorophenyl)thio>pyrido<3,2-d>pyrimidine-2,4-diamine 
• 95095-94-6 6-(3,4-Dichloro-phenylsulfanyl)-pyrido[3,2-d]pyrimidine-2,4-diamine 
• 95096-02-9 6-<(4-Fluorophenyl)sulfinyl>pyrido<3,2-d>pyrimidine-2,4-diamine 
• 95096-05-2 6-<(4-Fluoprophenyl)sulfonyl>pyrido<3,2-d>pyrimidine-2,4-diamine 
• 95096-01-8 6-(3,4-Dichloro-benzenesulfinyl)-pyrido[3,2-d]pyrimidine-2,4-diamine 
• 95095-93-5 6-(2,4,5-Trichloro-phenylsulfanyl)-pyrido[3,2-d]pyrimidine-2,4-diamine 
• 95096-04-1 6-(3,4-Dichloro-benzenesulfonyl)-pyrido[3,2-d]pyrimidine-2,4-diamine 
• 1048699-36-0 1-phenyl-3-(2-cyano-6-chloro-3-pyridyl)triazene 
• 1048699-11-1 6-chloro-4-anilino-pyrido[3,2-d][1,2,3]triazine 
• 1048699-16-6 6-chloro-4-(4-chloroanilino)pyrido[3,2-d]-1,2,3-triazine 

Relevant articles and documents

Optimization of 4,6-Disubstituted Pyrido[3,2-d]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth

Mitogen-activated protein kinase-interacting kinases (MNKs) and provirus integration in maloney murine leukemia virus kinases (PIMs) are downstream enzymes of cell proliferation signaling pathways associated with the resistance of tyrosine kinase inhibitors. MNKs and PIMs have complementary effects to regulate cap-dependent translation of oncoproteins. Dual inhibitors of MNKs and PIMs have not been developed. We developed a novel 4,6-disubstituted pyrido[3,2-d]pyrimidine compound 21o with selective inhibition of MNKs and PIMs. The IC50’s of 21o to inhibit MNK1 and MNK2 are 1 and 7 nM and those to inhibit PIM1, PIM2, and PIM3 are 43, 232, and 774 nM, respectively. 21o inhibits the growth of myeloid leukemia K562 and MOLM-13 cells with GI50’s of 2.1 and 1.2 μM, respectively. 21o decreases the levels ofp-eIF4E andp-4EBP1, the downstream products of MNKs and PIMs, as well as cap-dependent proteins c-myc, cyclin D1, and Mcl-1. 21o inhibits the growth of MOLM-13 cell xenografts without causing evident toxicity. 21o represents an innovative dual MNK/PIM inhibitor with a good pharmacokinetic profile.

Design and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors

A novel series of substituted pyrido[3,2-d]-1,2,3-triazines were designed and synthesized as Pim-1 inhibitors through scaffold hopping. Most of the derivatives showed potent in vitro Pim-1 inhibitory activities and anti-proliferative effects toward prosta

Carboxymethyl piperidine derivative

The present invention provides a novel compound useful in the prevention or treatment of nausea and vomiting associated with the administration of antineoplastics, the compound having an NK1 receptor-antagonizing effect, and an inhibitory effect on CYP3A4 that is attenuated to a greater extent than in aprepitant. Specifically, the present invention relates to a carboxymethyl piperidine derivative represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula, ring A is a benzene ring or the like, ring B is a pyridine ring or the like, R1 is a C1-6 alkyl or C1-6 alkoxy, R2 and R3 are hydrogen atoms or methyl, and n represents an integer of from 0 to 5.