95095-84-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-Amino-6-chloropyridine-2-carbonitrile is used as a building block in organic synthesis for the production of various pharmaceuticals and agrochemicals. Its unique structure and functional groups make it a valuable component in the development of new drugs and pesticides.
Used in Antifungal and Antiviral Applications:
3-Amino-6-chloropyridine-2-carbonitrile has been studied for its potential antifungal and antiviral properties. It can be used as an active ingredient in the development of new antimicrobial agents to combat resistant strains and emerging pathogens.
Used in Heterocyclic Compound Preparation:
3-Amino-6-chloropyridine-2-carbonitrile is used as a starting material for the preparation of heterocyclic compounds. Its presence in the synthesis process allows for the creation of diverse heterocyclic structures with potential applications in various fields, including medicine, materials science, and chemical research.
Used in Material and Chemical Process Development:
3-Amino-6-chloropyridine-2-carbonitrile is important in the development of new materials and chemical processes. Its unique properties and reactivity contribute to the advancement of innovative materials and processes with improved performance and functionality.

InChI:InChI=1/C6H4ClN3/c7-6-2-1-4(9)5(3-8)10-6/h1-2H,9H2

Upstream product

• 2402-78-0 2,6-dichloropyridine 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 7439-89-6 iron 
• 93683-65-9 6-chloro-3-nitropicolinonitrile 

Downstream Products

• 1206454-49-0 3-amino-6-chloro-pyridine-2-carbaldehyde 
• 866807-27-4 3-amino-6-chloro-pyridine-2-carboxylic acid 
• 93684-07-2 6-chloropyrido[3,2-d]pyrimidine-2,4-diamine 
• 2561455-12-5 6-chloro-2-methylpyrido[3,2-d]pyrimidin-4-amine 
• 1073182-90-7 3-amino-4-bromo-6-chloropyridine-2-carboxylic acid 
• 1499166-63-0 6-chloropyrido[3,2-d]pyrimidin-4-amine 
• 175358-01-7 3-amino-6-chloro-pyridine-2-carboxylic acid amide 
• 1048699-26-8 6-chloro-4-(2-fluoroanilino)pyrido[3,2-d][3,2-d]-1,2,3-triazine 
• 1048699-16-6 6-chloro-4-(4-chloroanilino)pyrido[3,2-d]-1,2,3-triazine 

Relevant academic research and scientific papers

Optimization of 4,6-Disubstituted Pyrido[3,2-d]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth

Mitogen-activated protein kinase-interacting kinases (MNKs) and provirus integration in maloney murine leukemia virus kinases (PIMs) are downstream enzymes of cell proliferation signaling pathways associated with the resistance of tyrosine kinase inhibitors. MNKs and PIMs have complementary effects to regulate cap-dependent translation of oncoproteins. Dual inhibitors of MNKs and PIMs have not been developed. We developed a novel 4,6-disubstituted pyrido[3,2-d]pyrimidine compound 21o with selective inhibition of MNKs and PIMs. The IC50’s of 21o to inhibit MNK1 and MNK2 are 1 and 7 nM and those to inhibit PIM1, PIM2, and PIM3 are 43, 232, and 774 nM, respectively. 21o inhibits the growth of myeloid leukemia K562 and MOLM-13 cells with GI50’s of 2.1 and 1.2 μM, respectively. 21o decreases the levels ofp-eIF4E andp-4EBP1, the downstream products of MNKs and PIMs, as well as cap-dependent proteins c-myc, cyclin D1, and Mcl-1. 21o inhibits the growth of MOLM-13 cell xenografts without causing evident toxicity. 21o represents an innovative dual MNK/PIM inhibitor with a good pharmacokinetic profile.

4, 6-disubstituted pyridine [3, 2-d] pyrimidine compound as well as preparation and application thereof

The invention belongs to the technical field of medicines. The invention relates to the field of pharmaceutical chemistry, in particular to a 4, 6-disubstituted pyridine [3, 2-d] pyrimidine compound and pharmaceutically acceptable salt thereof, a preparation method of the compound, a pharmaceutical composition taking the compound as an active ingredient, and application of the compound in preparation of an MNK inhibitor and drugs for treating and/or preventing various cancers and/or metabolic diseases. The present invention relates to compounds represented by formulas I, II, III or IV, and pharmaceutically acceptable salts, hydrates, solvates and metabolites thereof, wherein the variables are described in the claims and the description.

Design and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors

A novel series of substituted pyrido[3,2-d]-1,2,3-triazines were designed and synthesized as Pim-1 inhibitors through scaffold hopping. Most of the derivatives showed potent in vitro Pim-1 inhibitory activities and anti-proliferative effects toward prosta

Cyclohexylpropionic polypyridine deriv.

A problem of the present invention is to provide a new compound which has NK 1 receptor antagonist activity ,whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to cyclohexyl pyridine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. wherein, ring A is 4-fluoro-2-methylphenyl or the like; X is a hydrogen atom or the like; R 1 is carboxymethyl or the like; R 2 is alkyl or the like; Y is 0-2 or the like; U is-N(CH 3 )COC(CH 3 ) 2 -3,5-bistrifluoromethylphenyl or the like.

Carboxymethyl piperidine derivative

The present invention provides a novel compound useful in the prevention or treatment of nausea and vomiting associated with the administration of antineoplastics, the compound having an NK1 receptor-antagonizing effect, and an inhibitory effect on CYP3A4 that is attenuated to a greater extent than in aprepitant. Specifically, the present invention relates to a carboxymethyl piperidine derivative represented by formula (I) or a pharmacologically acceptable salt thereof. In the formula, ring A is a benzene ring or the like, ring B is a pyridine ring or the like, R1 is a C1-6 alkyl or C1-6 alkoxy, R2 and R3 are hydrogen atoms or methyl, and n represents an integer of from 0 to 5.

CARBOXYMETHYL PIPERIDINE DERIVATIVE

The present invention provides a new compound which has NK1 receptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to carboxymethyl piperidine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. Wherein, ring A is a benzene ring or the like; ring B is a pyridine ring or the like; R1 is C1-6 alkyl or C1-6 alkoxy; R2 and R3 are a hydrogen atom or methyl; and n is an integral number from 0 to 5.

Synthesis and biological evaluation of substituted 1,2,3-benzotriazines and pyrido[3,2-d]-1,2,3-triazines as inhibitors of vascular endothelial growth factor receptor-2

A novel series of substituted 1,2,3-benzotriazines and pyrido[3,2-d]-1,2,3- triazines were synthesized. The abilities of these compounds to inhibit the VEGFR-2 kinase activity and the proliferation of human microvascular endothelial cells (MVECs) were det

AROMATIC RING FUSED TRIAZINE DERIVATIVES AND USES THEREOF

The invention belongs to pharmaceutical field. The invention relates to the compounds according to Formula I, including their optically active forms, pharmaceutically acceptable salts or hydrates, and the pharmaceutical composition comprising thereof as a

THE AROMATIC RING TRIAZINE DERIVATIVES AND THE USES THEREOF

The invention belongs to pharmaceutical field. The invention relates to the compounds according to Formula I. including their optically active forms, pharmaceutically acceptable salts or hydrates, and the pharmaceutical composition comprising thereof as a

PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C.

Specifically substituted pyrido(3,2-d)pyrimidine derivatives having the structural formula (I) are useful for the treatment of hepatitis C.