95107-72-5Relevant academic research and scientific papers
Elaboration of the Benzazaphospholine Framework: a New Illustration of the Parham Protocol
Couture, Axel,Deniau, Eric,Grandclaudon, Pierre
, p. 1329 - 1330 (2007/10/02)
1-Alkyl-3-phenyl-1,3-benzazaphospholine oxides are efficiently prepared by Parham-type anionic cyclisation of ortho-lithiated N-alkyl-N-diphenylphosphinoylmethylaniline derivatives obtained by sequential treatment of the parent brominated compounds with methyllithium and tert-butyllithium.
Synthesis of indoles using (N-arylaminomethyl)diphenylphosphine oxides
Zorgdrager, Jan,Broekhof, Nico L. J. M.,Gen, Arne van der
, p. 441 - 444 (2007/10/02)
A new route for the synthesis of 1,3-disubstituted indoles, based on (N-arylaminomethyl)-diphenylphosphine oxide (1) chemistry, is described.Adducts 2, obtained by addition of the carbanions from 1 to aldehydes, were treated with p-toluenesulfonic acid to form the desired indoles 4 in good yields, without isolation of the intermediate amino ketones 3.
The synthesis of α-amino-substituted diphenylphosphine oxides
Broekhof, N. L. J. M.,Elburg, P. van,Gen, A. van der
, p. 312 - 316 (2007/10/02)
Four methods with differing but overlapping specificity are described for the synthesis of α-unsubstituted as well as α-substituted (aminomethyl)diphenylphosphine oxides.The first method is based on the Arbusov reaction, the second on a Mannich-type condensation of diphenylphosphine oxide with aldehydes and secondary amines, the third on the addition of Ph2P(O)H to enamines and the fourth on the reaction of anions derived from α-unsubstituted (aminomethyl)diphenylphosphine oxides with various electrophiles.
