23073-17-8

Basic information

• Product Name: 1H-Indole, 3-phenyl-1-(phenylmethyl)-
• CAS NO: 23073-17-8
• Molecular Formula: C21H17N
• Molecular Weight: 283.373
• Mol File: 23073-17-8.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 3-phenyl-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 3-phenyl-1-(phenylmethyl)-(23073-17-8)
• EPA Substance Registry System: 1H-Indole, 3-phenyl-1-(phenylmethyl)-(23073-17-8)

Safety Data

• Hazardous Substances Data: 23073-17-8(Hazardous Substances Data)

Upstream product

• 871506-88-6 1-benzyl-2,2-diphenyl-3-fluoroaziridine 
• 1504-16-1 3-phenyl-1H-indole 
• 100-39-0 benzyl bromide 
• 591-50-4 iodobenzene 
• 3377-71-7 N-benzylindole 
• 479675-59-7 (E)-1-phenylethan-1-one O-perfluorobenzoyl oxime 
• 120-72-9 indole 
• 100-44-7 benzyl chloride 
• 108-94-1 cyclohexanone 
• 1237588-95-2 N-benzyl-2-(α-phenylstyryl)aniline 
• 100-46-9 benzylamine 
• 5153-67-3 nitrostyrene 
• 758640-21-0 N-Benzylaniline 
• 100-52-7 benzaldehyde 

Downstream Products

• 1504-16-1 3-phenyl-1H-indole 

Relevant articles and documents

Fluoroaziridines as novel substrates in the modified Petasis reaction: synthesis of monofluorinated propargyl amines

Reaction of 2-fluoroaziridines with potassium alkynyltrifluoroborates in the presence of BF3·OEt2 leads to fluorinated propargyl amines in moderate to good yields. The reaction proceeds as an in situ isomerization of 2-fluoroaziridin

Arylation of indoles using cyclohexanones dually-catalyzed by niobic acid and palladium-on-carbons

3-Arylindoles were easily constructed from indoles and cyclohexanone derivatives using a combination of catalytic niobic acid-on-carbon (Nb2O5/C) and palladium-on-carbon (Pd/C) under heating conditions without any oxidants. The Lewis acidic Nb2O5/C promoted the nucleophilic addition of indoles to the cyclohexanones, and the subsequent dehydration and Pd/C-catalyzed dehydrogenation produced the 3-arylindoles. The additive 2,3-dimethyl-1,3-butadiene worked as a hydrogen acceptor to facilitate the dehydrogenation step.

Divergent Functionalization of N-Alkyl-2-alkenylanilines: Efficient Synthesis of Substituted Indoles and Quinolines

An efficient divergent functionalization of N-alkylated ortho-alkenylanilines to substituted indoles and quinolines has been accomplished by employing rhodium-catalyzed cross-dehydrogenative coupling and silver-mediated oxidative cyclization, respectively. The developed methods tolerate various functional groups and allow the synthesis of substituted indoles and quinolines in good to excellent yield. Synthetic utility is demonstrated through conversion to an indole with antimicrobial activity and C?H bond functionalization of 2-arylquinolines. Furthermore, a plausible mechanism was proposed based on preliminary mechanistic investigations.