95123-00-5

Upstream product

• 95122-89-7 2-(2-benzothiazolyldithio)-3-bromo-α-(1-methylethylidene)-4-oxo-1-azetidineacetic acid β-nitrobenzyl ester 
• 79634-01-8 p-nitrobenzoyl 6α-bromopenicillanate 1-oxide 
• 95122-89-7 p-nitrobenzyl 2-<2-oxo-3α-bromo-4-(benzothiazol-2-yldithio)azetidin-1-yl>-2-isopropenylacetate 

Downstream Products

• 904671-17-6 6α-bromo-2β-azidomethyl-2α-methylpenam-3α-carboxylic acid p-nitrobenzyl ester 
• 95123-02-7 p-nitrobenzyl 6α-bromo-2β-(nitrooxymethyl)-2α-methylpenam-3α-carboxylate 1,1-dioxide 
• 95123-01-6 p-nitrobenzyl 6α-bromo-2β-(nitrooxymethyl)-2α-methylpenam-3α-carboxylate 1-oxide 
• 95123-04-9 p-nitrobenzyl 6α-bromo-2β-(bromomethyl)-2α-methylpenam-3α-carboxylate 1-oxide 

Relevant academic research and scientific papers

Process for preparation of penam derivatives

The invention relates to novel processes for preparing penam derivatives, such as Tazobactam and derivatives thereof. The processes according to the invention encompass procedures for the protection and deprotection of the carboxylic group as well as for the oxidation of the sulphur moiety of penam derivatives. Additionally, the present invention relates to new intermediates for the production of penam derivatives, allowing the desired penam-derivatives to be formulated with high purity and in good yields.

Synthesis and β-lactamase inhibitory properties of 2β-[(acyloxy)methyl]-2-methylpenam-3α-carboxylic acid 1,1-dioxides

p-Nitrobenzyl 2β-[(benzoyloxy)methyl]-2α-methylpenam-3α-carboxylate was prepared by reaction of p-nitrobenzyl 2-[2-oxo-3α-bromo-4-(benzothiazol-2-yldithio)acetidin-1-yl]-2-isopropenyl acetate with silver benzoate in the presence of iodine. The resulting d