79634-01-8

Upstream product

• 79886-08-1 6α-bromopenicillanic acid 1-oxide potassium salt 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 100239-31-4 p-nitrobenzyl 6-bromopenicillanate 
• 91922-15-5 6-bromopenicillanic acid 
• 551-16-6 6-aminopenicillanic acid 
• 79703-02-9 6α-bromopenicillan-3α-carboxylic acid-1β-oxide 

Downstream Products

• 95122-89-7 p-nitrobenzyl 2-<2-oxo-3α-bromo-4-(benzothiazol-2-yldithio)azetidin-1-yl>-2-isopropenylacetate 
• 79634-02-9 p-nitrobenzoyl 2β-(chloromethyl)-2α-methyl-6α-bromopenem-3α-carboxylate 
• 623905-90-8 p-nitrobenzyl 2-[(3S,4R)-3-bromo-4-formylthio-2-oxoazetidin-1-yl]-3-methylbut-2-enoate 
• 769937-32-8 p-nitrobenzyl 2-[(3S,4R)-4-(benzothiazol-2-yldithio)-3-bromo-2-oxoazetidin-1-yl]-3-methylbut-2-enoate 
• 769937-24-8 p-nitrobenzyl (5R,6S)-6-bromo-6-[(R)-hydroxy-(2,3-dihydroimidazo[2,1-b]thiazol-6-yl)methyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 
• 623906-15-0 p-nitrobenzyl (5R,6S)-6-bromo-6-[(S)-hydroxy-(2,3-dihydroimidazo[2,1-b]thiazol-6-yl)methyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 
• 623564-16-9 (5R,6S)-6-bromo-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitrobenzyl ester 
• 95122-89-7 2-(2-benzothiazolyldithio)-3-bromo-α-(1-methylethylidene)-4-oxo-1-azetidineacetic acid β-nitrobenzyl ester 
• 95122-93-3 p-nitrobenzyl 6α-bromo-2β-<<(4-nitrobenzoyl)oxy>methyl>-2α-methylpenam-3α-carboxylate 1,1-dioxide 
• 95155-76-3 p-nitrobenzyl 6α-bromo-2β-<<(methoxybenzoyl)oxy>methyl>-2α-methylpenam-3α-carboxylate 1,1-dioxide 
• 95122-92-2 p-nitrobenzyl 6α-bromo-2β-<<(4-fluorobenzoyl)oxy>methyl>-2α-methylpenam-3α-carboxylate 1,1-dioxide 

Relevant academic research and scientific papers

A novel, mild, and facile method to prepare 6-methylidene pe nem derivatives

A novel and mild method was established to synthesize 6-methylidene penem compounds. This method entails a MgBr2/Et3N-promoted aldol-type condensation on 6-bromopenem 12 with an appropriately substituted aldehyde to yield the interme

Process for preparation of penam derivatives

The invention relates to novel processes for preparing penam derivatives, such as Tazobactam and derivatives thereof. The processes according to the invention encompass procedures for the protection and deprotection of the carboxylic group as well as for the oxidation of the sulphur moiety of penam derivatives. Additionally, the present invention relates to new intermediates for the production of penam derivatives, allowing the desired penam-derivatives to be formulated with high purity and in good yields.

PROCESS FOR PREPARING 6-ALKYLIDENE PENEM DERIVATIVES

The present invention provides a process of making compounds of Formula (I), which are useful for the treatment of bacterial infection or disease.

Synthesis and β-Lactamase Inhibitory Properties of 2β-(Chloromethyl)-2α-methylpenam-3α-carboxylic Acid 1,1-Dioxide

Potassium 2β-(chloromethyl)-2α-methylpenam-3α-carboxylate 1,1-dioxide (BL-P2013) and its pivaloyloxymethyl ester were prepared by the conversion of 6-aminopenicillanic acid to p-nitrobenzyl 6α-bromo-2,2-dimethylpenam-3α-carboxylate 1-oxide, which was rear