95127-08-5

Basic information

• Product Name: 2,6-dimethylphenyl 4-methylphenyl sulfone
• Synonyms: 2,6-dimethylphenyl 4-methylphenyl sulfone
• CAS NO: 95127-08-5
• Molecular Weight: 260.357
• Mol File: 95127-08-5.mol

Chemical Properties

• CAS DataBase Reference: 2,6-dimethylphenyl 4-methylphenyl sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethylphenyl 4-methylphenyl sulfone(95127-08-5)
• EPA Substance Registry System: 2,6-dimethylphenyl 4-methylphenyl sulfone(95127-08-5)

Safety Data

• Hazardous Substances Data: 95127-08-5(Hazardous Substances Data)

Upstream product

• 100379-00-8 2,6-dimethylbenzene boronic acid 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Relevant articles and documents

Cross-coupling of organoboronic acids and sulfinate salts using catalytic copper(II) acetate and 1,10-phenanthroline: synthesis of aryl and alkenylsulfones

A mild method for the preparation of aryl and alkenylsulfones from the cross-coupling reaction of organoboronic acids and sodium sulfinate salts is described. Optimized conditions utilize a catalytic amount of copper(II) acetate monohydrate with 1,10-phenanthroline as ligand in the presence of 4 ? molecular sieves. A co-solvent mixture of dichloromethane/DMSO was used, with reactions occurring at 40 °C under an atmosphere of oxygen. Reaction at room temperature also yields sulfone product, but in lower yields. The method tolerates a variety of substituents on the organoboronic acid, including amide, aldehyde, halide and nitro functionalities, as well as ortho-substituents. In general, the reaction is found to be less efficient using arylboronic acids bearing electron-withdrawing substituents, or using aryltrifluoroborate salts.

Three diphenyl sulfones

In 2,6-dimethylphenyl 4-nitrophenyl sulfone, C14H13-NO4S, (I), 2,6-dimethylphenyl 4-methylphenyl sulfone, C15H16O2S, (II), and 2-methylphenyl phenyl sulfone, C13H12Os