951325-77-2

Upstream product

• 951325-88-5 (5R,7S)-7-(tert-butyldimethylsilyl)oxy-5-hydroxy-1,7-diphenyl-2-hepten-1-one 
• 951325-91-0 (2S,4R,6R,E)-2-phenyl-6-styryltetrahydro-2H-pyran-4-ol 
• 1093413-44-5 C₁₉H₂₂O₃ 
• 1426679-82-4 (1S,3R)-1-phenylhex-5-ene-1,3-diol 
• 768-03-6 Phenyl vinyl ketone 
• 951325-93-2 (4R,6S)-6-(tert-butyldimethylsilyl)oxy-4-hydroxy-6-phenyl-1-hexene 
• 951325-90-9 C₁₉H₂₂O₃ 
• 951325-89-6 (5R,7S)-7-(tert-butyldimethylsilyl)oxy-1,5-dihydroxy-1,7-diphenyl-2-heptene 
• 412912-89-1 (S)-3-((tert-butyldimethylsilyl)oxy)-3-phenylpropanal 

Relevant academic research and scientific papers

A flexible enantioselective synthesis of (+)-centrolobine and 5-epi-diospongin-A using asymmetric transfer hydrogenation/tandem Grubbs cross-metathesis/oxy-Michael reaction as key steps

An efficient enantioselective synthesis of (+)-centrolobine and 5-epi-diospongin-A was achieved by the use of asymmetric transfer hydrogenation (ATH)/tandem Grubbs cross-metathesis/oxy-Michael reaction. Furthermore, this strategy allows for diastereodiver

Total syntheses of diospongins A and B

The total syntheses of diospongins A and B employing 2,6-disubstituted dihydropyranones as key intermediates are described.

Stereoselective synthesis of (-)-diospongins A and B and their stereoisomers at C-5

Antiosteoporotic diarylheptanoids (-)-diospongins A (1) and B (2) were synthesized stereoselectively. The key steps in the synthesis include a stereospecific PdII-catalyzed cyclization of chiral 1,5,7-trihydroxy-2-heptenes, 6a and 6b, to form c