951328-86-2

Basic information

• Product Name: (S)-tert-butyl methylthio-N-(1-phenylpyrrolidine-5-carbonyl)carbonoimidoylcarbamate
• Synonyms: (S)-tert-butyl methylthio-N-(1-phenylpyrrolidine-5-carbonyl)carbonoimidoylcarbamate
• CAS NO: 951328-86-2
• Molecular Weight: 363.481
• Mol File: 951328-86-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl methylthio-N-(1-phenylpyrrolidine-5-carbonyl)carbonoimidoylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl methylthio-N-(1-phenylpyrrolidine-5-carbonyl)carbonoimidoylcarbamate(951328-86-2)
• EPA Substance Registry System: (S)-tert-butyl methylthio-N-(1-phenylpyrrolidine-5-carbonyl)carbonoimidoylcarbamate(951328-86-2)

Safety Data

• Hazardous Substances Data: 951328-86-2(Hazardous Substances Data)

Upstream product

• 173998-77-1 N-(tert-butyloxycarbonyl)-S-methylisothiourea 
• 139983-29-2 (S)-1-phenylpyrrolidine-2-carboxylic acid 

Downstream Products

• 951329-12-7 (S)-tert-butyl N-(4-acetamido-3,5-dichlorobenzyl)-N'-(1-phenylpyrrolidine-5-carbonyl)carbamimidoylcarbamate 
• 951329-10-5 (S)-tert-butyl N-(4-amino-3,5-dichlorobenzyl)-N'-(1-phenylpyrrolidine-5-carbonyl)carbamimidoylcarbamate 

Relevant articles and documents

N-Aryl Pyrrolidine Derivatives as Beta-Secretase Inhibitors

There is provided a series of substituted N-aryl pyrrolidine derivatives of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R5′, R6, R7, and p as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.