951884-18-7

Basic information

• Product Name: N-Benzyl-2-bromo-5-fluorobenzamide
• Synonyms: Benzamide, 2-bromo-5-fluoro-N-(phenylmethyl)-
• CAS NO: 951884-18-7
• Molecular Formula: C₁₄H₁₁BrFNO
• Molecular Weight: 308.16
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 951884-18-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-Benzyl-2-bromo-5-fluorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-2-bromo-5-fluorobenzamide(951884-18-7)
• EPA Substance Registry System: N-Benzyl-2-bromo-5-fluorobenzamide(951884-18-7)

Safety Data

• Hazardous Substances Data: 951884-18-7(Hazardous Substances Data)

Upstream product

• 394-28-5 2-Bromo-5-fluorobenzoic acid 
• 100-46-9 benzylamine 

Downstream Products

• 1423016-41-4 (Z)-2-benzyl-3-benzylidene-6-fluoroisoindolin-1-one 

Relevant articles and documents

Rapid construction of C4-substituted phenanthridinones through palladium-catalyzed domino N-arylation/aryl-aryl coupling process

An excellent chemo- and regioselective palladium-catalyzed cascade intermolecular N-arylation/aryl-aryl coupling process has been developed. Employing Pd(TFA)2, PCy3?HBF4, K2CO3 and 1,4-dioxane in an oil bath at 100°C for 12 h, diverse C4-substituted phenanthridinones are synthesized from o-bromobenzamides in 42-92% yield. Broad substrate scope and excellent functional group tolerance are observed. The synthetic utility of this method is illustrated by the further derivatization to prepare multiple-substituted phenanthridinones in 30-75% yield.