95199-75-0Relevant academic research and scientific papers
STUDIES ON DIHYDROPYRIDINE DERIVATIVES-I 4,7-DIHYDROISOXAZOLOPYRIDINES
Yamamori, Teruo,Hiramatu, Yoshiharu,Sakai, Katunori,Adachi, Ikuo
, p. 913 - 918 (2007/10/02)
Reactions of 5-aminoisoxazoles with α,β-unsaturated ketones in t-butanol on heating afforded 4,7-dihydroisoxazolopyridines.However, when the reactions were carried out at 20 deg C using ethylene glycol as the solvent, the kinetically controlled amino adducts were obtained in excellent yields.The amino adducts were converted into the thermodynamically controlled 4,7-dihydroisoxazolopyridines by heating.Tentative mechanisms for the reaction are also presented.
