95205-15-5

Basic information

• Product Name: Benzamide, N-[2-oxo-1-(phenylmethyl)-2-(1-pyrrolidinyl)ethyl]-, (S)-
• CAS NO: 95205-15-5
• Molecular Formula: C20H22N2O2
• Molecular Weight: 322.407
• Mol File: 95205-15-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[2-oxo-1-(phenylmethyl)-2-(1-pyrrolidinyl)ethyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[2-oxo-1-(phenylmethyl)-2-(1-pyrrolidinyl)ethyl]-, (S)-(95205-15-5)
• EPA Substance Registry System: Benzamide, N-[2-oxo-1-(phenylmethyl)-2-(1-pyrrolidinyl)ethyl]-, (S)-(95205-15-5)

Safety Data

• Hazardous Substances Data: 95205-15-5(Hazardous Substances Data)

Upstream product

• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 85059-51-4 2-isocyano-3-phenyl-1-(pyrrolidin-1-yl)propan-1-one 
• 95205-41-7 PhCO-DL-Phe-Gly-GlyOEt 
• 95205-17-7 mononitrosated DL-benzoylphenylalanylglycine ethyl ester 
• 5046-57-1 PhCO-DL-Phe-GlyOEt 
• 95205-22-4 dinitrosated DL-benzoylphenylalanylglycylglycine ethyl ester 
• 123-75-1 pyrrolidine 

Relevant articles and documents

An aryne-based three-component access to α-aroylamino amides

Aryne chemistry has recently received widespread attention and isocyanides have been reported as efficient nucleophilic partners in a set of multicomponent transformations. In this study, we demonstrate that tertiary α-monosubstituted α-isocyanoacetamides are efficaciously coupled with water and benzyne to offer a direct and metal-free access to densely functionalized α-benzoylamino amides, without competing with the intramolecular cyclization to 5-aminooxazoles. Despite the formation of the aryl anion as a key intermediate, the reaction displays a stereoconservative course, allowing for the preparation of enantiomerically pure α-benzoylamino amides. Finally, the synthetic utility of the reported MCR was exemplified by the preparation of proglumide, a cholecystokinin antagonist.