952059-71-1

Basic information

• Product Name: 4-Hydroxy-7-methoxy-1,5-naphthyridine
• Synonyms: 4-Hydroxy-7-methoxy-1,5-naphthyridine;7-Methoxy-1H-[1,5]naphthyridin-4-one
• CAS NO: 952059-71-1
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17202
• Mol File: 952059-71-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Hydroxy-7-methoxy-1,5-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-7-methoxy-1,5-naphthyridine(952059-71-1)
• EPA Substance Registry System: 4-Hydroxy-7-methoxy-1,5-naphthyridine(952059-71-1)

Safety Data

• Hazardous Substances Data: 952059-71-1(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-7-methoxy-1,5-naphthyridine is a chemical compound with the molecular formula C12H9NO3. It is a naphthyridine derivative, which is a class of aromatic heterocyclic compounds containing a naphthalene ring with nitrogen atoms. 4-Hydroxy-7-methoxy-1,5-naphthyridine is known for its biological activities and has been studied for its potential as an anti-cancer and anti-inflammatory agent. It has also been investigated for its potential use in the treatment of neurodegenerative diseases. Additionally, 4-Hydroxy-7-methoxy-1,5-naphthyridine has been identified as a natural product in certain plant species and has been studied for its pharmacological properties.

Upstream product

• 64436-92-6 3-amino-5-methoxypyridine 
• 625-92-3 3,5-dibromopyridine 
• 50720-12-2 3-bromo-5-methoxypyridine 
• 952059-70-0 5-[(5-methoxy-pyridin-3-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione 

Downstream Products

• 952059-69-7 8-chloro-3-methoxy-1,5-naphthyridine 
• 1071528-55-6 3-(4-(4-(7-methoxy-1,5-naphthyridin-4-yloxy)phenylamino)phthalazin-1-yl)benzonitrile 
• 1071528-82-9 N¹-(7-methoxy-1,5-naphthyridin-4-yl)-N⁴-(4-phenylphthalazin-1-yl)benzene-1,4-diamine 
• 952059-82-4 2-[2-methoxy-4-(7-methoxy-1,5-naphthyridin-4-yloxy)phenyl]acetic acid 
• 952059-83-5 methyl 2-[2-methoxy-4-(7-methoxy-1,5-naphthyridin-4-yloxy)phenyl]acetate 
• 952059-89-1 methyl 2-[3-methoxy-5-(7-methoxy-1,5-naphthyridin-4-yloxy)pyridin-2-yl]acetate 
• 1071541-08-6 4-chloro-7-hydroxy-1,5-naphthyridine 
• 1071535-20-0 5-methoxy-N-(4-(7-methoxy-1,5-naphthyridin-4-yloxy)phenyl)pyridazin-3-amine 
• 1071528-83-0 N-(6-(7-methoxy-1,5-naphthyridin-4-yloxy)pyridin-3-yl)-4-phenylphthalazin-1-amine 
• 1071528-77-2 4-(4-tert-butylphenyl)-N-(4-(7-methoxy-1,5-naphthyridin-4-yloxy)phenyl)phthalazin-1-amine 
• 1071528-74-9 N-(4-(7-methoxy-1,5-naphthyridin-4-yloxy)phenyl)-4-(4-methoxyphenyl)phthalazin-1-amine 
• 1071528-72-7 4-ethyl-N-(4-(7-methoxy-1,5-naphthyridin-4-ylthio)phenyl)-6-p-tolylpyridazin-3-amine 
• 1071539-92-8 4-(7-methoxy-1,5-naphthyridin-4-ylthio)benzenamine 
• 1071539-89-3 4-(7-methoxy-1,5-naphthyridin-4-yloxy)benzenamine 

Relevant articles and documents

Aurora Kinase Modulators and Method of Use

The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

NAPHTHYRIDINE DERIVATIVES

The invention concerns naphthyridine derivatives of Formula (Ia) or (Ib) or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, G1, G2, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders or disease states associated with angiogenesis and/or vascular permeability.