95207-68-4

Usage

Uses

Used in Organic Synthesis:
3-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-ONE is used as a key intermediate in the synthesis of various organic compounds due to its reactive functional groups and unique ring system.
Used in Medicinal Chemistry:
In the pharmaceutical industry, 3-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-ONE is used as a building block for the development of novel therapeutic agents. Its potential biological activity and versatile chemical structure make it a valuable component in the design of new drugs.
Used in Material Science:
3-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-ONE is utilized in the development of advanced materials, such as polymers and coatings, owing to its structural properties and reactivity. Its incorporation can lead to materials with improved properties and novel functionalities.
Used in Drug Discovery and Development:
3-AMINO-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-ONE is of interest for further research in drug discovery and development due to its potential biological activity. Its unique structure and reactivity may contribute to the creation of new therapeutic agents with specific pharmacological properties.

Upstream product

• 7507-93-9 3-nitro-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one 
• 826-73-3 1-Benzosuberone 

Downstream Products

• 870679-45-1 9-chloro-1-(2′,4′-dichlorophenyl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxylic acid 
• 870679-49-5 ethyl 9-chloro-1-(2′,4′-dichlorophenyl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxylate 
• 740842-30-2 (9-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl) carbamic acid benzyl ester 
• 740842-31-3 [N-5-hydroxy(1,2,3,4,5-pentahydrobenzo[a][7]annulene-7-yl) (phenylmethoxy) carboxamide], 
• 35872-55-0 3-Benzyloxy-6,7,8,9-tetrahydrobenzocyclohepten-5-one 
• 5454-03-5 3-hydroxy-6,7,8,9-tetrahydro-5H-benzo(a)cyclohepten-5-one 
• 21413-77-4 3-chloro-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one 

Relevant academic research and scientific papers

Vinyl Carbocations Generated under Basic Conditions and Their Intramolecular C-H Insertion Reactions

Here we report the surprising discovery that high-energy vinyl carbocations can be generated under strongly basic conditions, and that they engage in intramolecular sp3 C-H insertion reactions through the catalysis of weakly coordinating anion salts. This approach relies on the unconventional combination of lithium hexamethyldisilazide base and the commercially available catalyst, triphenylmethylium tetrakis(pentafluorophenyl)borate. These reagents form a catalytically active lithium species that enables the application of vinyl cation C-H insertion reactions to heteroatom-containing substrates.

A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells

A new fluorescence-forming probe, coumOCT, designed by fusing cyclooctyne with a coumarin fluorophore was successfully used for the imaging of azido-glycoconjugates in living HeLa cells. This probe is cell-permeable and generates fluorescence after triazole formation, thus minimizing the background signal and enabling the real-time intracellular imaging of glycoconjugate trafficking.

Benzimidazolone bioisosteres of potent GluN2B selective NMDA receptor antagonists

Overactivation of the NMDA receptor is associated with excitotoxic events leading to neurodegenerative processes as observed during the development of Alzheimer's disease, ParFnson's disease, Chorea Huntington and epilepsy. Negative allosteric modulators

REACTIVE LABELLING COMPOUNDS AND USES THEREOF

Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.

REACTIVE LABELLING COMPOUNDS AND USES THEREOF

Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.

BENZOCYCLOOCTYNE COMPOUNDS AND USES THEREOF

Provided are benzocyclooctyne compounds of formula (I). These compounds undergo strain-promoted azide-alkyne cyclo additions (SPAAC) without presence of toxic metal catalysts. The provided compounds are useful for diagnosis and imaging of azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.

MACROCYCLIC BENZOFUSED PYRIMIDINE DERIVATIVES

Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.

Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2′, 4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7] cyclohepta[1,2-c]pyrazole-3-carboxamide

A series of analogues of 8-chloro-1-(2′,4′-dichlorophenyl)-AT- piperidin-1-yl-1,4,5,6-tetrahydrobenzo-[6,7]cyclohepta[1,2-c] pyrazole-3-carboxamide 4a (NESS 0327) (Ruiu, S.; Pinna, G. A.; Marchese, G.; Mussinu, J. M.; Saba, P.; Tambaro, S.; Casti, P.; Var

OXAZOLIDINONE DERIVATIVES N-SUBSTITUTED BY A BICYCLIC RING, FOR USE AS ANTIBACTERIAL AGENTS

Compounds of formula (I) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compoun

ANTIBACTERIAL AGENTS

Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.