95211-47-5Relevant academic research and scientific papers
Structure based design of selective SHP2 inhibitors by De novo design, synthesis and biological evaluation
Liu, Wen-Shan,Jin, Wen-Yan,Zhou, Liang,Lu, Xing-Hua,Li, Wei-Ya,Ma, Ying,Wang, Run-Ling
, p. 759 - 774 (2019/07/17)
SHP2 phosphatase, encoded by the PTPN11 gene, is a non-receptor PTP, which plays an important role in growth factor, cytokine, integrin, hormone signaling pathways, and regulates cellular responses, such as proliferation, differentiation, adhesion migrati
Synthesis and antibacterial activity of some novel triazolothienopyrimidines
Raghu Prasad, Mailavaram,Prashanth, John,Shilpa, Kalghatgi,Pran Kishore, Deb
, p. 557 - 560 (2008/02/09)
A novel series of some novel 5-substituted-1,2,4-triazolo[4,3-c]8,9,10- trihydrocyclopenta/8,9,10,11,12-pentahydrocyclohepta[ b]thieno[3,2-e]pyrimidin- 3-thiones has been synthesized. The intermediates 4-chloro-2-substituted-5,6,7- trihydrocyclopenta/5,6,
Studies with polyfunctionality substituted heterocycles: Novel syntheses of thienopyrimido-1,2,4-triazoles
El-Gazzar,Hegab,Swelam,Aly
, p. 123 - 136 (2007/10/03)
Several 3-substituted-(un)-cyclohepta(b)thieno[2,3-d]pyrimido[3,4-a]-1,2,4-triazoles 10, 11, 12, 13, and 14 were prepared by reaction of an appropriate substituted 2-amino-3-cyanothiophene 1 with aliphatic acids or benzoyl chloride. Also the fusion of 1 with urea, thiourea to give the corresponding 2-oxo or thioxo-4-aminopyrimidine derivatives 6a, b and other reactions of compound 1 are reported.
Thieno[2.3-d]-4-pyrimidones: Synthesis, structure and pharmacological properties
Perrissin,Favre,Luu-Duc,et al.
, p. 420 - 424 (2007/10/02)
The cyclization of 2-amino-3-carbethoxy or -carboxamido thophenes yields substituted or unsubstituted 4-pyrimidones. Their structure and their 'lactam-lactam' tautomerism have been investigated by i.r. spectroscopy. The eighteen compounds synthesized were tested for a few pharmacological activities. They have no anti-edema activity except for two. Ten of them have shown an analgesic activity equal or superior to that of acetyl salicylic acid.
