952115-28-5

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 952115-16-1 2-hydroxy-3-phenyl-hexa-3,5-dienoic acid ethyl ester 
• 13633-26-6 4-phenylbut-1-en-3-yne 

Downstream Products

• 952115-29-6 C₁₇H₂₀O₄ 
• 952115-30-9 C₂₉H₃₁NO₃ 

Relevant academic research and scientific papers

Enantioselective reductive coupling of 1,3-enynes to glyoxalates mediated by hydrogen: Asymmetric synthesis of β,γ-unsaturated α-hydroxy esters

Catalytic hydrogenation of 1,3-enynes 1a-8a in the presence of ethyl glyoxalate at ambient pressure and temperature using a rhodium catalyst modified by (R)-(3,5-tBu-4-MeOPh)-MeO-BIPHEP results in highly regio- and enantioselective reductive coupling to furnish the corresponding a-hydroxy esters 1b-8b. As demonstrated by the elaboration of a-hydroxy ester 1b, the terminal and internal olefin moieties embodied by the diene side chain are subject to selective manipulation, one over the other.