13633-26-6

Basic information

• Product Name: Benzene, 3-buten-1-ynyl- (9CI)
• Synonyms: Benzene, 3-buten-1-ynyl- (9CI)
• CAS NO: 13633-26-6
• Molecular Formula: C₁₀H₈
• Molecular Weight: 128.17052
• Mol File: 13633-26-6.mol
• Article Data: 42

Chemical Properties

• Boiling Point: 96 °C(Press: 20 Torr)
• Appearance: /
• Density: 0.948 g/cm3
• CAS DataBase Reference: Benzene, 3-buten-1-ynyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 3-buten-1-ynyl- (9CI)(13633-26-6)
• EPA Substance Registry System: Benzene, 3-buten-1-ynyl- (9CI)(13633-26-6)

Safety Data

• Hazardous Substances Data: 13633-26-6(Hazardous Substances Data)

Upstream product

• 3182-70-5 4-phenylbut-2-ynyl bromide 
• 593-60-2 Vinyl bromide 
• 536-74-3 phenylacetylene 
• 74752-53-7 4-propargyl-2-phenyl-Δ²-1,3,4-oxadiazolin-5-one 
• 67-56-1 methanol 
• 24182-36-3 [(1Z)-2-bromobuta-1,3-dien-1-yl]benzene 
• 160721-87-9 (Z)-2-Chloro-1-phenyl-1,3-butadiene 
• 25295-64-1 1,1-dibromo-2-methyl-3-phenylcyclopropane 
• 28495-06-9 4-phenyl-2-butyn-1-ol 
• 247129-85-7 (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate 
• 74-86-2 acetylene 
• 33603-90-6 (2Z)-2-bromo-3-phenyl-2-propenal 
• 2768-02-7 (vinyl)trimethoxylsilane 
• 1199-02-6 5-phenyl-3H-[1,3,4]oxadiazol-2-one 

Downstream Products

• 13633-27-7 1-(hexa-1,2-dienyl)benzene 
• 124475-74-7 2-(2-Phenylethynyl-aziridin-1-yl)-isoindole-1,3-dione 
• 214552-98-4 2-vinyl-1,3-terphenyl 
• 104-51-8 1-butylbenzene 
• 1048027-79-7 1-(furan-2-yl)-2-methyl-4-phenylbut-3-yn-1-ol 

Relevant articles and documents

Cobalt-catalyzed hydrohydrazination of dienes and enynes: Access to allylic and propargylic hydrazides

(Chemical Equation Presented) The cobalt-catalyzed hydrohydrazination reaction of dienes and enynes is presented. Allylic and propargylic hydrazines were obtained in synthetically useful yields (allylic amines, 60-90%; propargylic amines, 47-83%) and good chemo- and regioselectivity.

Pd/Cu-Catalyzed Vinylation of Terminal Alkynes with (2-Bromoethyl)diphenylsulfonium Triflate

The potential of (2-bromoethyl)diphenylsulfonium triflate to be a powerful vinylation reagent was determined by the Sonogashira cross-coupling reactions with terminal alkynes. The vinylation proceeded smoothly at 25 °C under Pd/Cu catalysis to afford a variety of 1- and 2-unsubstituted 1,3-enynes in moderate to excellent yields. This protocol represents the first application of (2-haloethyl)diphenylsulfonium triflate as a CH═CH2 transfer source in organic synthesis.

Radical Carbonyl Propargylation by Dual Catalysis

Carbonyl propargylation has been established as a valuable tool in the realm of carbon–carbon bond forming reactions. The 1,3-enyne moiety has been recognized as an alternative pronucleophile in the above transformation through an ionic mechanism. Herein, we report for the first time, the radical carbonyl propargylation through dual chromium/photoredox catalysis. A library of valuable homopropargylic alcohols bearing all-carbon quaternary centers could be obtained by a catalytic radical three-component coupling of 1,3-enynes, aldehydes and suitable radical precursors (41 examples). This redox-neutral multi-component reaction occurs under very mild conditions and shows high functional group tolerance. Remarkably, bench-stable, non-toxic, and inexpensive CrCl3 could be employed as a chromium source. Preliminary mechanistic investigations suggest a radical-polar crossover mechanism, which offers a complementary and novel approach towards the preparation of valuable synthetic architectures from simple chemicals.

Transition metal-free formal hydro/deuteromethylthiolation of unactivated alkenes

Methylthioether is involved in the methylthiotransfer process in organisms, and therefore its functionality is of paramount importance to living organisms. Several methods for the installation of the methylthio group in small molecules have been reported previously; however, procedures starting from unactivated alkenes are rare. Herein, we report a formal hydro/deuteromethylthiolation of alkenes by using dimethyl(methylthio)sulfonium trifluoromethanesulfonate as the stimulator and sodium borohydride/deuteride as the hydrogen/deuterium source. The process represents a mild, transition metal-free and methanethiol-free route towards the synthesis of methylthioethers from unactivated alkenes. This journal is