95212-95-6

Upstream product

• 95215-03-5 [5,10,15,20-tetrakis(3-methoxyphenyl)porphyrinato]copper(II) 
• 29114-93-0 meso-tetra(m-methoxyphenyl)porphyrin 
• 95215-03-5 (5,10,15,20-tetra-m-methoxyphenylporphyrinato)copper(II) 

Downstream Products

• 1338245-63-8 C₄₈H₃₆CuN₄O₅ 
• 1412456-51-9 [2-amino-3-nitro-5,10,15,20-tetrakis(3-methoxyphenyl)porphyrinato]copper(II) 

Relevant academic research and scientific papers

Direct β-amination reaction in porphyrin systems - A simple route to compounds containing two nitrogen substituents at both β-positions of the same pyrrole unit

The direct β-amination of porphyrin derivatives is described. 2-Nitro-meso-tetraarylporphyrins (zinc and copper complexes) react with N,N,N-trimethylhydrazinium iodide (TMHI) in the presence of a base (KOH/DMSO system, ca 70-80 °C) to give products of nucleophilic aromatic substitution of hydrogen. In this process, the nucleophilic replacement of a H-atom by an NH2 group takes place. The products obtained, bearing two neighbouring nitrogen substituents on the same pyrrole ring, are valuable intermediates for various synthetic uses.

APPLICATION OF β-FUNCTIONALIZED DIHYDROXY-CHLORINS FOR PDT

The present invention provides methods to obtain biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence

Synthesis of β-functionalized Temoporfin derivatives for an application in photodynamic therapy

The synthesis of novel β-functionalized derivatives of the clinically used photosensitizer Temoporfin has been achieved by nucleophilic addition reactions to a corresponding diketo chlorin. The β-substituted dihydroxychlorin products exhibit a strong abso

Control of Reactivity at the Porphyrin Periphery by Metal Ion Co-ordination: a General Method for Specific Nitration at the β-Pyrrolic Position of 5,10,15,20-Tetraarylporphyrins

The site of nitration by nitrogen dioxide on a range of metalloporphyrins has been found to be dependent on the co-ordinated metal; copper(II), nickel(II), and palladium(II) complexes are nitrated specifically on the porphyrin β-pyrrolic position while magnesium(II), zinc(II), chloroiron(III), and cobalt(II) complexes also give products which result from reaction at the meso-position.