95215-57-9

Basic information

• Product Name: 3-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)propanoic acid
• Synonyms: 3-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)propanoic acid
• CAS NO: 95215-57-9
• Molecular Weight: 287.315
• Mol File: 95215-57-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)propanoic acid(95215-57-9)
• EPA Substance Registry System: 3-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)propanoic acid(95215-57-9)

Safety Data

• Hazardous Substances Data: 95215-57-9(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 95215-49-9 1-acetyl-3-hydroxy-2-methylpyrid-4-one 
• 107-95-9 3-amino propanoic acid 
• 118-71-8 Maltol 
• 61049-69-2 3-O-benzylmaltol 

Downstream Products

• 771459-53-1 methyl 3-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)propanoate 
• 1469815-76-6 3-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)propanehydrazide 
• 1312425-36-7 C₃₈H₃₈N₄O₆ 
• 1312425-34-5 C₄₂H₅₄N₆O₆ 
• 1256623-63-8 C₂₆H₂₄N₂O₃ 
• 732232-07-4 3-(3-Benzyloxy-2-methyl-4-oxo-4H-pyridin-1-yl)-propionic acid ethyl ester 
• 95215-87-5 1-<2'-<(succinimidyloxy)carbonyl>ethyl>-2-methyl-3-(benzyloxy)-4(1H)-pyridinone 
• 1332867-82-9 C₅₃H₃₈CuN₆O₃ 
• 1332867-81-8 C₅₃H₃₈N₆O₃Zn 
• 1332867-88-5 C₆₀H₄₄CuN₆O₃ 

Relevant articles and documents

Multifunctional diamine AGE/ALE inhibitors with potential therapeutical properties against Alzheimer's disease

An important part of pathogenesis of Alzheimer's disease (AD) is attributed to the contribution of AGE (Advanced Glycation Endproducts) and ALE (Advanced Lipid peroxidation Endproducts). In order to attenuate the progression of AD, we designed a new type of molecules that consist of two trapping parts for reactive carbonyl species (RCS) and reactive oxygen species (ROS), precursors of AGE and ALE, respectively. These molecules also chelate transition metals, the promoters of ROS formation. In this paper, synthesis of the new AGE/ALE inhibitors and evaluation of their physicochemical and biological properties (carbonyl trapping capacity, antioxidant activity, Cu2+-chelating capacity, cytotoxicity and protective effect against in?vitro MGO-induced apoptosis in the model AD cell-line PC12) are described. It is found that compounds 40b and 51e possess promising therapeutic potentials for treating AD.

Multicellular aggregation of maltol-modified cells triggered by Fe 3+ ions

The synthesis of a maltol-derived hydrazide is described which, once attached to a cell surface, induces rapid multicellular aggregation selectively in the presence of Fe3+ ions. Heterocellular aggregates are also reported. The Royal Society of Chemistry 2013.

Synthesis, physicochemical properties, and biological evaluation of N- substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potential

The synthesis of a range of novel bidentate ligands containing the chelating moiety 3-hydroxy-4(1H)-pyridinone is described. The pK(a) values of the ligands and the stability constants of their iron(III) complexes have been determined. The crystal structures of one of the ligands and one of the iron(III) complexes are presented. The distribution coefficients of the ligands are reported and are related to the ability of the ligands to remove iron from hepatocytes. The influence of 3-hydroxy-4(1H)-pyridinones on oxidative damage to cells is described. In contrast to the iron chelator in current therapeutic use, desferrioxamine-B, many of the bidentate ligands described in this study are orally active in iron-overloaded mice.