952150-42-4

Basic information

• Product Name: 5(S)-(acetylaminomethyl)-3-(3,5-difluoro-4-(1-(tertbutoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one
• Synonyms: 5(S)-(acetylaminomethyl)-3-(3,5-difluoro-4-(1-(tertbutoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one
• CAS NO: 952150-42-4
• Molecular Weight: 469.489
• Mol File: 952150-42-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5(S)-(acetylaminomethyl)-3-(3,5-difluoro-4-(1-(tertbutoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5(S)-(acetylaminomethyl)-3-(3,5-difluoro-4-(1-(tertbutoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one(952150-42-4)
• EPA Substance Registry System: 5(S)-(acetylaminomethyl)-3-(3,5-difluoro-4-(1-(tertbutoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one(952150-42-4)

Safety Data

• Hazardous Substances Data: 952150-42-4(Hazardous Substances Data)

Upstream product

• 1138150-46-5 [1,2,5]triazepane-1-carboxylic acid tert-butyl ester 
• 952150-41-3 5(S)-(aminomethyl)-3-(3,5-difluoro-4-(1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl) [1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one 
• 952150-40-2 5(R)-(azidomethyl)-3-(3,5-difluoro-4-(1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one 
• 952150-39-9 5(R)-(hydroxymethyl)-3-(3,5-difluoro-4-(1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)[1,2,5]triazepan-5-yl)phenyl)oxazolidin-2-one 
• 952150-38-8 5-(4-benzyloxycarbonylamino-2,6-difluorophenyl)[1,2,5]triazepane-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 1443005-31-9 5-(2,6-difluoro-4-nitrophenyl)[1,2,5]triazepane-1-carboxylic acid tert-butyl ester 
• 66684-58-0 3,4,5-trifluoronitrobenzene 

Downstream Products

• 952151-26-7 (S)-N-((3-(3,5-difluoro-4-(1-(hydroxyacetyl)[1,2,5]triazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide 
• 952151-16-5 (S)-N-((3-(3,5-difluoro-4-(10-oxo-5,6,8,9-tetrahydro-10H-4,4b,7,9a-tetraazabenzo[a]azulen-7-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide 
• 952152-79-3 (S)-N-((3-(3,5-difluoro-4-(2-bromo-10-oxo-5,6,8,9-tetrahydro-10H-4,4b,7,9a-tetraazabenzo[a]azulen-7-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide 
• 952152-77-1 (S)-N-((3-(3,5-difluoro-4-(2-chloro-10-oxo-5,6,8,9-tetrahydro-10H-4,4b,7,9a-tetraazabenzo[a]azulen-7-yl)-phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide 
• 952152-81-7 (S)-N-((3-(3,5-difluoro-4-(2-amino-10-oxo-5,6,8,9-tetrahydro-10H-4,4b,7,9a-tetraazabenzo[a]azulen-7-yl)pheny-l)-2-oxo-5-oxazolidinyl)methyl)acetamide 

Relevant articles and documents

Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit

We synthesized a series of oxazolidinone analogues bearing a N-hydroxyacetyl-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit as homologues of an earlier drug candidate, eperezolid. Several of these compounds exhibited potent in vitro antibacterial activities towards not only Gram-positive, but also Gram-negative and linezolid-resistant pathogens. Compounds 21a and 21b, bearing a thiocarbamate side chain, showed high in vivo activity against methicillin-resistant Staphylococcus aureus SR3637, together with a promising safety profile in terms of weak inhibition of monoamine oxidase and cytochrome P450 isozymes.