952152-87-3

Upstream product

• 952151-44-9 C₂₀H₂₇F₂N₃O₈S 
• 1443005-59-1 O-methyl (S)-N-(3-(4-(1-(tert-butoxycarbonyl)[1,2,5]oxadiazepan-5-yl)-3,5-difluorophenyl)-2-oxooxazolidin-5-yl)methylthiocarbamate 
• 952151-45-0 5(R)-(azidomethyl)-3-(3,5-difluoro-4-(2-(tertbutoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one 
• 952151-43-8 5(R)-(hydroxymethyl)-3-(3,5-difluoro-4-(2-(tertbutoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one 
• 952151-42-7 5-(4-benzyloxycarbonylamino-2,6-difluorophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester 
• 952151-41-6 5-(2,6-difluoro-4-nitrophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester 
• 66684-58-0 3,4,5-trifluoronitrobenzene 

Downstream Products

• 1254784-79-6 (S)-N-((3-(3,5-difluoro-4-(2-(hydroxyacetyl)[1,2,5]oxadiazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-O-methylthiocarbamate 
• 952153-46-7 (S)-N-((3-(3,5-difluoro-4-(2-(methylcarbamoyl)-[1,2,5]oxadiazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-O-methylthiocarbamate 
• 1489240-42-7 (S)-N-((3-(3,5-difluoro-4-(2-carbamoyl-[1,2,5]oxadiazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-O-methylthiocarbamate 
• 952153-52-5 (S)-N-((3-(3,5-difluoro-4-(2-(methoxycarbamoyl)[1,2,5]oxadiazepan-5-yl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-O-methylthiocarbamate 

Relevant academic research and scientific papers

Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit

We synthesized a series of oxazolidinone analogues bearing a N-hydroxyacetyl-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit as homologues of an earlier drug candidate, eperezolid. Several of these compounds exhibited potent in vitro antibacterial activities towards not only Gram-positive, but also Gram-negative and linezolid-resistant pathogens. Compounds 21a and 21b, bearing a thiocarbamate side chain, showed high in vivo activity against methicillin-resistant Staphylococcus aureus SR3637, together with a promising safety profile in terms of weak inhibition of monoamine oxidase and cytochrome P450 isozymes.