95236-94-5

Basic information

• Product Name: 4-chloro-N-(4-methoxyphenyl)benzenecarbothioamide
• CAS NO: 95236-94-5
• Molecular Formula: C₁₄H₁₂ClNOS
• Molecular Weight: 277.7692
• Mol File: 95236-94-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 393°C at 760 mmHg
• Flash Point: 191.5°C
• Density: 1.309g/cm³
• Vapor Pressure: 2.2E-06mmHg at 25°C
• Refractive Index: 1.674
• CAS DataBase Reference: 4-chloro-N-(4-methoxyphenyl)benzenecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(4-methoxyphenyl)benzenecarbothioamide(95236-94-5)
• EPA Substance Registry System: 4-chloro-N-(4-methoxyphenyl)benzenecarbothioamide(95236-94-5)

Safety Data

• Hazardous Substances Data: 95236-94-5(Hazardous Substances Data)

Upstream product

• 1073-67-2 4-vinylbenzyl chloride 
• 104-94-9 4-methoxy-aniline 
• 165543-77-1 4-Chloro-dithiobenzoic acid p-tolyl ester 
• 20849-33-6 phenyl p-chlorobenzenedithiocarboxylate 
• 39153-42-9 p-Chlor-dithiobenzoesaeure-p-chlorphenylester 
• 4018-82-0 4-chloro-N-(4-methoxyphenyl)benzamide 
• 165543-78-2 4-Chloro-dithiobenzoic acid 4-bromo-phenyl ester 
• 1878-66-6 4-chlorophenylacetic Acid 

Relevant articles and documents

Thioamide derivative and preparation method thereof

The invention discloses a thioamide derivative. The structural formula of the thioamide derivative is represented by the formula (I) or the formula (II). The invention also provides a preparation method of the thioamide derivative. According to the preparation method, alkali metal salts are taken as the alkalis, amines are directly coupled with alkenes and sulfur, and by selecting the alkali, twodifferent thioamide derivatives represented by the formula (I) and the formula (II) can be prepared from same raw materials. The provided preparation method has the advantages that the raw materials are cheap and easily available, the synthesis method is simple, and the cost is largely reduced. The provided thioamide derivatives can be used in fields such as bioactive molecules, drug synthesis, and the like, and has a wide application range.

Decarboxylative thioamidation of arylacetic and cinnamic acids: A new approach to thioamides

A new decarboxylative strategy has been developed for the synthesis of thioamides via a three-component reaction involving arylacetic or cinnamic acids, amines and elemental sulfur powder, without the need of a transition metal and an external oxidant.

ANTIMYCOBACTERIAL THIOBENZANILIDES

A group of 30 thiobenzanilides active against Mycobacterium kansasii have been synthesized and their 1H NMR and UV spectra and RM values (TLC on silica gel impregnated with methylsilicone oil) have been measured.From the correlation between the chemical shifts of the thioamide proton in the 1H NMR spectra and the Hammett constants it can be concluded that the substituents in both aromatic rings uniformly affect the electron density of the thioamide group.The antimycobacterial activity is probably connected with local molecular parameters and can be considered to be approximately additive with respect to both parts of the molecule.