95245-16-2

Upstream product

• 56-18-8 bis(3-aminopropyl)amine 
• 74272-78-9 2,3-dibenzyloxybenzoic acid 
• 81254-86-6 2,3-bis(benzyloxy)-1-((2-thioxothiazolidin-1-yl)carbonyl)benzene 

Downstream Products

• 74272-84-7 N,N-bis(2,3-dihydroxybenzamidopropyl)-(2,3-dihydroxybenzoyl)glycinamide 
• 74272-83-6 N,N-bis(2,3-dibenzyloxybenzamidopropyl)-(2,3-dibenzyloxybenzoyl)glycinamide 
• 103185-30-4 (4R,5S)-2-(2,3-Dihydroxy-phenyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid bis-[3-(2,3-dihydroxy-benzoylamino)-propyl]-amide 
• 103185-30-4 fluvibactin 
• 357628-45-6 N⁴-(N-carbobenzyloxy-D-threonyl)-N¹,N⁷-bis[2,3-bis(benzyloxy)benzoyl]norspermidine 
• 357628-44-5 N⁴-(N-carbobenzyloxy-L-threonyl)-N¹,N⁷-bis[2,3-bis(benzyloxy)benzoyl]norspermidine 

Relevant academic research and scientific papers

Catechol-Based Functionalizable Ligands for Gallium-68 Positron Emission Tomography Imaging

Four tris-bidentate catecholamide (CAM) ligands were synthesized, characterized, and evaluated as ligands for radiolabeling of gallium-68 for positron emission tomography (PET). Three of those ligands, 2,2-Glu-CAM, 3,3-Glu-CAM, and TREN-bisGlyGlu-CAM, incorporate ligand caps that contain a pendant carboxylic group for further conjugation to targeting moieties. The acyclic ligands all exhibited high (>80%) radiolabeling yields after short reaction times (a distinct advantage over macrocyclic analogues that display slower kinetics. The stabilities of the four GaIII complexes are comparable to or higher than those of other acyclic ligands used for gallium-68 PET imaging, such as desferrioxamine, with pGa values ranging from 21 to >24, although the functionalizable ligands are less stable than the parent GaIII-TREN-CAM. In vivo imaging studies and ex vivo pharmacokinetic and biodistribution studies indicate that the parent [68Ga]Ga-TREN-CAM is stable in vivo but is rapidly cleared in a renal pathway. The rapid and mild radiolabeling conditions, high radiolabeling yields, and high stability in human serum (>95%) render TREN-bisGlyGlu-CAM a promising candidate for gallium-68 chelation.

COMPOUNDS, COMPLEXES, AND METHODS USEFUL FOR DETECTING AND/OR TREATING BACTERIAL PATHOGENS

Compounds and complexes that can be useful as enterobactin probes not necessary are disclosed herein. Methods of detecting bacteria and/or methods of determining susceptibility of bacteria to an antibiotic using such compounds and complexes are also disclosed herein.

Significance of asymmetric sites in choosing siderophores as deferration agents

The syntheses of the microbial iron chelators L-fluviabactin, its unnatural enantiomer, D-fluviabactin, L-homofluviabactin, and L-agrobactin, are described. The key steps involve the selective bis-acylation of the terminal nitrogens of norspermidine, sper