952487-49-9Relevant academic research and scientific papers
SCALEABLE PREPARATION OF POLYKETIDES
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Paragraph 0287-0288; 0291-0292; 0346; 0361-0364, (2021/02/12)
Disclosed herein, inter alia, are methods of making polyketide compounds.
ANTI-CANCER POLYKETIDE COMPOUNDS
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, (2013/10/21)
Provided herein, inter alia, are anticancer polyketides. The uses of the polyketides described herein include treatment of cancer, for example, through regulation of the spliceosome and detection of spliceosome inhibition.
Structure of FD-895 revealed through total synthesis
Villa, Reymundo,Mandel, Alexander L.,Jones, Brian D.,La Clair, James J.,Burkart, Michael D.
, p. 5396 - 5399 (2013/01/15)
The total synthesis of FD-895 was completed through a strategy that featured the use of a tandem esterification ring-closing metathesis (RCM) process to construct the 12-membered macrolide and a modified Stille coupling to append the side chain. These stu
Synthesis of (4R,6S,7R)-7-hydroxy-4,6-dimethyl-3-nonanone and (3R,5S,6R)-6-hydroxy-3,5-dimethyl-2-octanone
Sabitha, Gowravaram,Srinivas, Chitti,Maruthi, Chittapragada,Yadav, Jhillu Singh
experimental part, p. 2071 - 2079 (2012/03/27)
The synthesis of (4R,6S,7R)-7-hydroxy-4,6-dimethyl-3-nonanone and (3R,5S,6R)-6-hydroxy-3,5-dimethyl-2-octanone is described as their acetates using a desymmetrization strategy as well as an Evans syn aldol strategy.
A synthetic entry to pladienolide B and FD-895
Mandel, Alexander L.,Jones, Brian D.,La Clair, James J.,Burkart, Michael D.
, p. 5159 - 5164 (2008/04/07)
Presented within are syntheses of the pladienolide B and FD-895 side-chains, as well as models of the essential ring-closing metathesis and Stille coupling that will be used to complete their total syntheses. Several analogs of the pladienolide B side-cha
