952591-48-9Relevant academic research and scientific papers
PYRIDAZINE BASED ALPHA-HELIX MIMETICS
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Page/Page column 27, (2009/04/25)
The synthesis of new α-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available building block, 6. These scaffolds may be thought of as synthetic counterparts of amphip
Synthesis of pyridazine-based scaffolds as α-helix mimetics
Volonterio, Alessandro,Moisan, Lionel,Rebek Jr., Julius
, p. 3733 - 3736 (2008/02/12)
The synthesis of several amphiphilic, nonpeptidic scaffolds that mimic the presentation of i, i + 3 or i + 4, and i + 7 residues of a peptide α-helix is described. The approach uses a pyridazine core, and the synthesis involves only a few steps and minimi
